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Chlorin e6 trisodium

Name: Chlorin e6 trisodium
Brand: TargetMol
SKU: TXB-00042
Rating: 4.5 (1 reviews)

(Synonyms: Ce6 trisodium) Copy Product Info

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Synonyms: Ce6 trisodium

Catalog No. TXB-00042 Copy Product Info

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Chlorin e6 trisodium (Ce6 trisodium) is a water-soluble derivative of chlorophyll and belongs to the chlorin photosensitizers with an absorption wavelength range of 600–670 nm. Upon photoexcitation, Chlorin e6 trisodium can produce characteristic red fluorescence for real-time observation of tumor boundaries and disease progression. Chlorin e6 trisodium can be used in photodynamic therapy (PDT)-related research and fluorescence diagnosis research of malignant tumors such as bladder cancer and related neoplastic lesions.

Cas No. 72984-36-2

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For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:Black

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Product Introduction

Bioactivity

Description	Chlorin e6 trisodium (Ce6 trisodium) is a water-soluble derivative of chlorophyll and belongs to the chlorin photosensitizers with an absorption wavelength range of 600–670 nm. Upon photoexcitation, Chlorin e6 trisodium can produce characteristic red fluorescence for real-time observation of tumor boundaries and disease progression. Chlorin e6 trisodium can be used in photodynamic therapy (PDT)-related research and fluorescence diagnosis research of malignant tumors such as bladder cancer and related neoplastic lesions.
Targets & IC50	HeLa cells:13 μM, HeLa cells:0.83 μM
In vitro	Methods: HeLa cells were treated with Chlorin e6 trisodium and incubated for 24 hours before irradiation. Results: Chlorin e6 trisodium exhibited dark toxicity in HeLa cells with an IC₅₀ of 13 μM, and exhibited phototoxicity with an IC₅₀ of 0.83 μM [3].
In vivo	Methods: Balb/c nude mice bearing MGH xenografts were treated with Chlorin e6 trisodium (2.5‑5 mg/kg, intravenous injection, single dose) combined with laser irradiation. Results: Chlorin e6 trisodium exhibited high phototoxicity and induced significantly higher tumor necrosis in tumor tissues [1][2].
Synonyms	Ce6 trisodium

Chemical Properties

Molecular Weight	662.62
Formula	C₃₄H₃₃N₄Na₃O₆
Cas No.	72984-36-2
Smiles	[O-]C(CC1=C2[C@H]([C@@H](C(C=C3NC(C(C=C)=C3C)=CC4=NC(C(CC)=C4C)=CC5=C(C)C(C([O-])=O)=C1N5)=N2)C)CCC([O-])=O)=O.[Na+].[Na+].[Na+]

Storage & Solubility Information

Storage

Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 4.00 mg/mL (6.04 mM), Sonication is recommended.

H2O: 4.00 mg/mL (6.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.5092 mL	7.5458 mL	15.0916 mL	75.4580 mL
5 mM	0.3018 mL	1.5092 mL	3.0183 mL	15.0916 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: Chlorin e6 trisodium chemical structure | Chlorin e6 trisodium in vivo | Chlorin e6 trisodium in vitro | Chlorin e6 trisodium formula | Chlorin e6 trisodium molecular weight