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ABT-510 acetate

Name: ABT-510 acetate
Brand: TargetMol
SKU: T24997
Price: 54 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24997Cas No. 442526-87-6

Alias ABT 510 acetate

ABT-510 acetate is an endogenous anti-angiogenic TSP peptide inhibitor, a thrombospondin analog, with anti-inflammatory, anti-cancer and anti-angiogenic activity that induces apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer.ABT-510 acetate reduces angiogenesis and inflammatory responses in a mouse model of inflammatory bowel disease. ABT-510 acetate reduces angiogenesis and inflammation in mouse models of inflammatory bowel disease (IBD) and can be used in cancer research, particularly in epithelial ovarian cancer, as well as in inflammatory bowel disease (IBD).

ABT-510 acetate

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Purity: 95.07%

Catalog No. T24997Alias ABT 510 acetateCas No. 442526-87-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$54	In Stock	In Stock
5 mg	$128	In Stock	In Stock
10 mg	$193	In Stock	In Stock
25 mg	$327	In Stock	In Stock
50 mg	$489	In Stock	In Stock
100 mg	$713	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:95.07%

Appearance:Solid

Color:White

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COA HPLC MS

Product Introduction

Bioactivity

Description	ABT-510 acetate is an endogenous anti-angiogenic TSP peptide inhibitor, a thrombospondin analog, with anti-inflammatory, anti-cancer and anti-angiogenic activity that induces apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer.ABT-510 acetate reduces angiogenesis and inflammatory responses in a mouse model of inflammatory bowel disease. ABT-510 acetate reduces angiogenesis and inflammation in mouse models of inflammatory bowel disease (IBD) and can be used in cancer research, particularly in epithelial ovarian cancer, as well as in inflammatory bowel disease (IBD).
In vitro	ABT-510 acetate (1, 5, 10, 20, 50 nM; 24 h) induces apoptosis in ID 8 cells and increases apoptosis incidence in human epithelial cancer cell lines SKOV3, OVCAR3, and CAOV3.[1] ABT-510 acetate (0-10 μM; 7 days) inhibits NO-stimulated growth and invasion of vascular cells into the extracellular matrix and blocks tumor-driven vascular cell growth, NO-driven cGMP flux, and CD36-mediated fatty acid uptake.[3]
In vivo	ABT-510 acetate (100 mg/kg; i.p.; once daily for 90 days) induces apoptosis in vivo and significantly reduces epithelial ovarian tumor size, ascites volume, and secondary lesion spread in mice.[1] ABT-510 acetate (60 mg/kg; subcutaneous osmotic minipump; once daily for 7 days) reduces angiogenesis and inflammation in a mouse model of inflammatory bowel disease.[2]
Synonyms	ABT 510 acetate

Chemical Properties

Molecular Weight	1054.28
Formula	C₄₈H₈₇N₁₃O₁₃
Cas No.	442526-87-6
Smiles	C(C)(O)=O.C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC(CNC(CN(C(C)=O)C)=O)=O)[C@H](C)C)=O)[C@H](CC)C)=O)[C@@H](C)O)=O)CCC)=O)[C@H](CC)C)=O)CCCNC(=N)N)(=O)N1[C@H](C(NCC)=O)CCC1
Relative Density.	no data available
Sequence	Ac-Sar-Gly-Val-D-aIle-Thr-Nva-Ile-Arg-Pro-NHEt.CH3CO2H
Sequence Short	GGVXTXIRP

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 90 mg/mL (85.37 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	0.9485 mL	4.7426 mL	9.4851 mL	47.4257 mL
5 mM	0.1897 mL	0.9485 mL	1.8970 mL	9.4851 mL
10 mM	0.0949 mL	0.4743 mL	0.9485 mL	4.7426 mL
20 mM	0.0474 mL	0.2371 mL	0.4743 mL	2.3713 mL
50 mM	0.0190 mL	0.0949 mL	0.1897 mL	0.9485 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc