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LPA2 antagonist 1

Name: LPA2 antagonist 1
Brand: TargetMol
SKU: T15786
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15786Cas No. 1017606-66-4

LPA2 antagonist 1 is a highly efficient LPA2 antagonist.

LPA2 antagonist 1

😃Good

Purity: 99.85%

Catalog No. T15786Cas No. 1017606-66-4

LPA2 antagonist 1 is a highly efficient LPA2 antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	-	In Stock
5 mg	$289	-	In Stock
10 mg	$463	-	In Stock
25 mg	$812	-	In Stock
50 mg	$1,160	-	In Stock
1 mL x 10 mM (in DMSO)	$318	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.85%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	LPA2 antagonist 1 is a highly efficient LPA2 antagonist.
Targets&IC50	LPA2:17 nM
In vitro	LPA2 antagonist 1 inhibits LPA-induced Erk phosphorylation in a concentration-dependent manner. LPA2 antagonist 1 inhibits the proliferation of HCT-116 colon cancer cells induced by LPA in a dose-dependent manner. [1]

Chemical Properties

Molecular Weight	500.47
Formula	C₂₀H₂₃Cl₂N₅O₂S₂
Cas No.	1017606-66-4
Smiles	N([C@H](CN1CCN(S(=O)(=O)C2=CC(Cl)=C(Cl)C=C2)CC1)C)C3=C4C(C(C)=CS4)=NC=N3
Relative Density.	1.453 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMF: 80 mg/mL (159.85 mM), Sonication is recommended.

DMSO: 80 mg/mL (159.85 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (6.59 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9981 mL	9.9906 mL	19.9812 mL	99.9061 mL
5 mM	0.3996 mL	1.9981 mL	3.9962 mL	19.9812 mL
10 mM	0.1998 mL	0.9991 mL	1.9981 mL	9.9906 mL
20 mM	0.0999 mL	0.4995 mL	0.9991 mL	4.9953 mL
50 mM	0.0400 mL	0.1998 mL	0.3996 mL	1.9981 mL
100 mM	0.0200 mL	0.0999 mL	0.1998 mL	0.9991 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc