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Anti-Phospho-SMC1A (Ser957) Antibody (1T770)
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Catalog No. TMAH-00967
Alias Structural maintenance of chromosomes protein 1A, SMC1L1, SMC-1-alpha, SMC1A (p-Ser957), SMC1A (p-S957), SMC-1A, SMC1, SMC protein 1A, SB1.8, Sb1.8, p-SMC1A (Ser957), p-SMC1A (S957), Phospho-SMC1A (S957), KIAA0178, DXS423E
Anti-Phospho-SMC1A (Ser957) Antibody (1T770) is an antibody targeting Phospho-SMC1A (Ser957). Anti-Phospho-SMC1A (Ser957) Antibody (1T770) can be used in ELISA, WB.
Anti-Phospho-SMC1A (Ser957) Antibody (1T770)
Anti-Phospho-SMC1A (Ser957) Antibody (1T770)
😃Good
Catalog No. TMAH-00967Alias Structural maintenance of chromosomes protein 1A, SMC1L1, SMC-1-alpha, SMC1A (p-Ser957), SMC1A (p-S957), SMC-1A, SMC1, SMC protein 1A, SB1.8, Sb1.8, p-SMC1A (Ser957), p-SMC1A (S957), Phospho-SMC1A (S957), KIAA0178, DXS423E
Anti-Phospho-SMC1A (Ser957) Antibody (1T770) is an antibody targeting Phospho-SMC1A (Ser957). Anti-Phospho-SMC1A (Ser957) Antibody (1T770) can be used in ELISA, WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $209 | 7-10 days | |
| 100 μL | $347 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Rabbit Monoclonal Application: ELISA, WB Reactivity: Human |
| Alias | Structural maintenance of chromosomes protein 1A, SMC1L1, SMC-1-alpha, SMC1A (p-Ser957), SMC1A (p-S957), SMC-1A, SMC1, SMC protein 1A, SB1.8, Sb1.8, p-SMC1A (Ser957), p-SMC1A (S957), Phospho-SMC1A (S957), KIAA0178, DXS423E |
| Ig Type | Rabbit IgG |
| Clone | 1T770 |
| Reactivity | Human |
| Verified Activity | Western Blot -Positive WB detected in 293 whole cell lysate(treated with Calyculin A or not) -All lanes Phospho-SMC1A antibody at 1.11μg/ml -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 160 KDa -Observed band size: 160 KDa |
| Application | ELISA, WB |
| Recommended Dose | WB:1:500-1:5000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Nucleus. Chromosome. Chromosome, centromere, kinetochore. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function. Integral component of the functional centromere-kinetochore complex at the kinetochore region during mitosis. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human Phospho-SMC1A (S957) |
| Antigen Species | Human |
| Gene ID | 8243 |
| Uniprot ID | |
| Biology Area | Cell Biology |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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