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BAY-826

Name: BAY-826
Brand: TargetMol
SKU: T38930
Price: 69 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38930Cas No. 1448316-08-2

BAY-826 is a novel, potent and selective TIE-2 inhibitor that inhibits TIE-2 phosphorylation and can be used to study tumors.

BAY-826

🥰Excellent

Purity: 98%

Catalog No. T38930Cas No. 1448316-08-2

BAY-826 is a novel, potent and selective TIE-2 inhibitor that inhibits TIE-2 phosphorylation and can be used to study tumors.

Pack Size	Price	Availability	Quantity
1 mg	$69	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98%

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COA HNMR HPLC MS

Product Introduction

Bioactivity

Description	BAY-826 is a novel, potent and selective TIE-2 inhibitor that inhibits TIE-2 phosphorylation and can be used to study tumors.
Targets&IC50	Tie2:1.6 nM (Kd)
In vitro	BAY-826 is a selective and potent inhibitor of TIE-2 (dissociation constant = 1.6 nM) and binds with similar high affinity to only 4 of 456 tested kinases,namely, TIE-1,DDR1, DDR2, and Serine/threonine-protein kinase 10(LOK) (dissociation constant = 0.9, 0.4, 1.3, and 5.9 nM[1].
In vivo	A single oral dose of BAY-826 at 100, 50, or 25 mg/kg effectively inhibits ang-1-induced autophosphorylation of TIE-2 in mouse lungs[1].

Chemical Properties

Molecular Weight	558.53
Formula	C₂₆H₁₉F₅N₆OS
Cas No.	1448316-08-2
Smiles	Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C#N)-n1ccn2nc(cc12)-c1cccnc1
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (143.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.58 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7904 mL	8.9521 mL	17.9041 mL	89.5207 mL
5 mM	0.3581 mL	1.7904 mL	3.5808 mL	17.9041 mL
10 mM	0.1790 mL	0.8952 mL	1.7904 mL	8.9521 mL
20 mM	0.0895 mL	0.4476 mL	0.8952 mL	4.4760 mL
50 mM	0.0358 mL	0.1790 mL	0.3581 mL	1.7904 mL
100 mM	0.0179 mL	0.0895 mL	0.1790 mL	0.8952 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc