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Eravacycline dihydrochloride

Name: Eravacycline dihydrochloride
Brand: TargetMol
SKU: T11227L
Price: 123 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11227LCas No. 1334714-66-7

Alias TP-434-046, TP-434 dihydrochloride

Eravacycline dihydrochloride (TP-434-046) is a potent and broad-spectrum antibacterial agent against six E. coli (MICs: 0.125-0.25 mg/L).

Eravacycline dihydrochloride

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Purity: 99.68%

Catalog No. T11227LAlias TP-434-046, TP-434 dihydrochlorideCas No. 1334714-66-7

Eravacycline dihydrochloride (TP-434-046) is a potent and broad-spectrum antibacterial agent against six E. coli (MICs: 0.125-0.25 mg/L).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$123	In Stock	In Stock
5 mg	$372	In Stock	In Stock
10 mg	$619	In Stock	In Stock
25 mg	$1,090	In Stock	In Stock
50 mg	$1,930	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.68%

Appearance:Solid

Color:Yellow

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COA LCMS FNMR HNMR

Product Introduction

Bioactivity

Description	Eravacycline dihydrochloride (TP-434-046) is a potent and broad-spectrum antibacterial agent against six E. coli (MICs: 0.125-0.25 mg/L).
In vitro	Eravacycline shows inhibitory activity against A. baumannii, including isolates that are resistant to sulbactam, SM 7338, and BAY 41-6551(MIC50/90 = 0.5/1 mg/L)[1]. Eravacycline shows potent broad-spectrum activity against 90% of the isolates for all species panels (MIC90 0.008-2 μg/mL) except those of Pseudomonas aeruginosa and Burkholderia cenocepacia (MIC90 = 32 μg/mL). Eravacycline is active against multidrug-resistant bacteria including β-lactamases and antibiotics, including carbapenem resistance[4].
In vivo	Eravacycline(3.125-50 mg/kg) shows mean fAUC/MIC magnitude associated with net stasis and 1-log kill endpoint of 27.97 and 32.60[2]. In mouse septicemia models, Eravacycline is efficacious against Staphylococcus aureus and demonstrates 50% protective dose values of ≤1 mg/kg. The PD50s are 1.2-4.4 mg/kg against Escherichia coli isolates[5].
Synonyms	TP-434-046, TP-434 dihydrochloride

Chemical Properties

Molecular Weight	631.48
Formula	C₂₇H₃₃Cl₂FN₄O₈
Cas No.	1334714-66-7
Smiles	Cl.Cl.[H][C@@]12Cc3c(F)cc(NC(=O)CN4CCCC4)c(O)c3C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (237.54 mM), Sonication is recommended.

H2O: 45 mg/mL (71.26 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (7.92 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5836 mL	7.9179 mL	15.8358 mL	79.1791 mL
5 mM	0.3167 mL	1.5836 mL	3.1672 mL	15.8358 mL
10 mM	0.1584 mL	0.7918 mL	1.5836 mL	7.9179 mL
20 mM	0.0792 mL	0.3959 mL	0.7918 mL	3.9590 mL
50 mM	0.0317 mL	0.1584 mL	0.3167 mL	1.5836 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0158 mL	0.0792 mL	0.1584 mL	0.7918 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc