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Eravacycline dihydrochloride

Name: Eravacycline dihydrochloride
Brand: TargetMol
SKU: T11227L
Price: 123 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11227LCas No. 1334714-66-7

Alias TP-434-046, TP-434 dihydrochloride

Eravacycline dihydrochloride (TP-434-046) is a potent and broad-spectrum antibacterial agent against six E. coli (MICs: 0.125-0.25 mg/L).

Eravacycline dihydrochloride

🥰Excellent

Purity: 95%

Catalog No. T11227LAlias TP-434-046, TP-434 dihydrochlorideCas No. 1334714-66-7

Eravacycline dihydrochloride (TP-434-046) is a potent and broad-spectrum antibacterial agent against six E. coli (MICs: 0.125-0.25 mg/L).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$123	In Stock	In Stock
5 mg	$372	In Stock	In Stock
10 mg	$619	In Stock	In Stock
25 mg	$1,090	In Stock	In Stock
50 mg	$1,930	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:95%

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COA HNMR LCMS FNMR

Product Introduction

Bioactivity

Description	Eravacycline dihydrochloride (TP-434-046) is a potent and broad-spectrum antibacterial agent against six E. coli (MICs: 0.125-0.25 mg/L).
In vitro	Eravacycline shows inhibitory activity against A. baumannii, including isolates that are resistant to sulbactam, SM 7338, and BAY 41-6551(MIC50/90 = 0.5/1 mg/L)[1]. Eravacycline shows potent broad-spectrum activity against 90% of the isolates for all species panels (MIC90 0.008-2 μg/mL) except those of Pseudomonas aeruginosa and Burkholderia cenocepacia (MIC90 = 32 μg/mL). Eravacycline is active against multidrug-resistant bacteria including β-lactamases and antibiotics, including carbapenem resistance[4].
In vivo	Eravacycline(3.125-50 mg/kg) shows mean fAUC/MIC magnitude associated with net stasis and 1-log kill endpoint of 27.97 and 32.60[2]. In mouse septicemia models, Eravacycline is efficacious against Staphylococcus aureus and demonstrates 50% protective dose values of ≤1 mg/kg. The PD50s are 1.2-4.4 mg/kg against Escherichia coli isolates[5].
Synonyms	TP-434-046, TP-434 dihydrochloride

Chemical Properties

Molecular Weight	631.48
Formula	C₂₇H₃₃Cl₂FN₄O₈
Cas No.	1334714-66-7
Smiles	Cl.Cl.[H][C@@]12Cc3c(F)cc(NC(=O)CN4CCCC4)c(O)c3C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 135.0 mg/mL (213.8 mM), Sonication is recommended.

H2O: 45.0 mg/mL (71.3 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (7.92 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5836 mL	7.9179 mL	15.8358 mL	79.1791 mL
5 mM	0.3167 mL	1.5836 mL	3.1672 mL	15.8358 mL
10 mM	0.1584 mL	0.7918 mL	1.5836 mL	7.9179 mL
20 mM	0.0792 mL	0.3959 mL	0.7918 mL	3.9590 mL
50 mM	0.0317 mL	0.1584 mL	0.3167 mL	1.5836 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0158 mL	0.0792 mL	0.1584 mL	0.7918 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc