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IWP-O1

Name: IWP-O1
Brand: TargetMol
SKU: T5342
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T5342Cas No. 2074607-48-8

IWP-O1, a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.

IWP-O1

🥰Excellent

Purity: 99.12%

Catalog No. T5342Cas No. 2074607-48-8

IWP-O1, a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.

Pack Size	Price	Availability
2 mg	$33	In Stock
5 mg	$58	In Stock
10 mg	$103	In Stock
25 mg	$166	In Stock
50 mg	$238	In Stock
100 mg	$337	In Stock
200 mg	$483	In Stock
1 mL x 10 mM (in DMSO)	$64	In Stock

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Batch Information

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Purity:99.12%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	IWP-O1, a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
Targets&IC50	Porcn:80 pM (EC50, in L-Wnt-STF cells)
In vitro	IWP-O1functions by preventing the secretion of Wnt proteins. IWP-O1 effectively suppressed the phosphorylation of Dvl2/3 in HeLa cells. At the same time, the phosphorylation of low-density lipoprotein receptor-related protein 6 (LRP6). IWP-O1 suppresses Wnt signaling in L-Wnt-STF cells with an EC50 value of 80 pM.

Chemical Properties

Molecular Weight	432.48
Formula	C₂₆H₂₀N₆O
Cas No.	2074607-48-8
Smiles	O=C(Cn1nnc(c1-c1ccccc1)-c1ccncc1)Nc1ccc(cn1)-c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (138.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.62 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3122 mL	11.5612 mL	23.1225 mL	115.6123 mL
5 mM	0.4624 mL	2.3122 mL	4.6245 mL	23.1225 mL
10 mM	0.2312 mL	1.1561 mL	2.3122 mL	11.5612 mL
20 mM	0.1156 mL	0.5781 mL	1.1561 mL	5.7806 mL
50 mM	0.0462 mL	0.2312 mL	0.4624 mL	2.3122 mL
100 mM	0.0231 mL	0.1156 mL	0.2312 mL	1.1561 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc