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Tropicamide

Name: Tropicamide
Brand: TargetMol
SKU: T1281
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1281Cas No. 1508-75-4

Alias Ro 1-7683

Tropicamide (Ro 1-7683) is a synthetic muscarinic antagonist with anticholinergic properties similar to atropine. Upon ocular administration, it binds to and blocks muscarinic receptors in the sphincter and ciliary muscles, inhibiting cholinergic responses and causing pupil dilation and ciliary muscle paralysis. Tropicamide is used as a diagnostic agent to induce short-duration mydriasis and cycloplegia.

Tropicamide

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Purity: 99.94%

Catalog No. T1281Alias Ro 1-7683Cas No. 1508-75-4

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$40	In Stock	In Stock
500 mg	$64	In Stock	In Stock
1 g	$85	-	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Tropicamide (Ro 1-7683) is a synthetic muscarinic antagonist with anticholinergic properties similar to atropine. Upon ocular administration, it binds to and blocks muscarinic receptors in the sphincter and ciliary muscles, inhibiting cholinergic responses and causing pupil dilation and ciliary muscle paralysis. Tropicamide is used as a diagnostic agent to induce short-duration mydriasis and cycloplegia.
Targets&IC50	M4 mAChR:8 nM
In vitro	At a concentration of 0.5%, Nepafenac significantly inhibits (46%) the breakdown of the blood-retinal barrier, leading to a 65% reduction in retinal edema, and almost completely suppresses PGE2 synthesis (96%). Nepafenac's bioavailability in ocular tissue is notably higher. Its inhibitory action on COX-1 is weaker (IC50: 64.3 μM). In rabbits, Nepafenac inhibits prostaglandin synthesis within the retina/choroid (55%) and in the iris/ciliary body (85-95%). Compared to control mice, Nepafenac substantially reduces choroidal neovascularization and ischemia-induced retinal neovascularization and also slows the increase in ischemia-induced retinal VEGF mRNA expression. In ocular and metastatic animal models, Nepafenac delays the progression of malignant tumors and decreases the weight of choroidal melanoma. In retinal microvessels of diabetic rats with insulin deficiency, Nepafenac markedly suppresses retinal prostaglandin E (2), superoxide, cyclooxygenase-2, and leukostasis, but does not affect vascular endothelial growth factor and nitric oxide. In diabetic rats, the compound significantly inhibits the number of dUTP nick end labeling (TUNEL) positive capillary cells, pericytes, and acellular capillaries mediated by transferase.
Synonyms	Ro 1-7683

Chemical Properties

Molecular Weight	284.35
Formula	C₁₇H₂₀N₂O₂
Cas No.	1508-75-4
Smiles	C(C(N(CC=1C=CN=CC1)CC)=O)(CO)C2=CC=CC=C2
Relative Density.	1.161g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (211.01 mM), Sonication is recommended.

Ethanol: 53 mg/mL (186.39 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.03 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5168 mL	17.5840 mL	35.1679 mL	175.8396 mL
5 mM	0.7034 mL	3.5168 mL	7.0336 mL	35.1679 mL
10 mM	0.3517 mL	1.7584 mL	3.5168 mL	17.5840 mL
20 mM	0.1758 mL	0.8792 mL	1.7584 mL	8.7920 mL
50 mM	0.0703 mL	0.3517 mL	0.7034 mL	3.5168 mL
100 mM	0.0352 mL	0.1758 mL	0.3517 mL	1.7584 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc