MCP-1/CCL2 Protein, Human, Recombinant (His)

Monocyte chemoattractant protein 1 (MCP-1), also called CCL2, belongs to a group of CC chemokines located in chromosome 17q11.2. MCP-1 protein interacts with chemokine C-C motif receptor 2 (CCR2) to activate and recruit monocytes, macrophages, CD4+ T cells and immature dendritic cells to the site of infection. The presence of MCP-1 protein in an adequate concentration is important for granuloma formation and M. tuberculosis clearance.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Pack Size	Availability	Price/USD
50 μg	In stock	$ 245.00
100 μg	5 days	$ 413.00
200 μg	5 days	$ 693.00
500 μg	5 days	$ 2,130.00

Pack Size

Availability

Price/USD

Quantity

50 μg

In stock

$ 245.00

100 μg

5 days

$ 413.00

200 μg

5 days

$ 693.00

500 μg

5 days

$ 2,130.00

Biological Information

Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with mouse CCR2. The ED50 for this effect is 20-200 ng/mL.

Description

Species	Human
Expression System	Yeast
Tag	His
Accession Number	P13500
Synonyms	SCYA2, HC11, MCAF, HSMCR30, MCP-1, MCP1, GDCF-2, SMC-CF, chemokine (C-C motif) ligand 2
Construction	A DNA sequence encoding the human CCL2 (NP_002973.1) (Gln24-Thr99) was expressed with a polyhistidine tag at the C-terminus.
Protein Purity	> 95 % as determined by SDS-PAGE.
Molecular Weight	Approxiamtely 10.1 kDa

Endotoxin	Please contact us for more information.
Formulation	Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution	A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage	Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	Monocyte chemoattractant protein 1 (MCP-1), also called CCL2, belongs to a group of CC chemokines located in chromosome 17q11.2. MCP-1 protein interacts with chemokine C-C motif receptor 2 (CCR2) to activate and recruit monocytes, macrophages, CD4+ T cells and immature dendritic cells to the site of infection. The presence of MCP-1 protein in an adequate concentration is important for granuloma formation and M. tuberculosis clearance.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy