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Indomethacin sodium hydrate

Name: Indomethacin sodium hydrate
Brand: TargetMol
SKU: T22346
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22346Cas No. 74252-25-8

Alias Indometacin sodium hydrate

Indomethacin sodium hydrate is an effective orally active, competitive, and reversible inhibitor of COX-1 and COX-2, with IC50 values of 18 nM and 26 nM, respectively. It possesses anti-inflammatory, anticancer, and antimicrobial activities and is commonly used in research related to cancer, inflammation, and viral infections. Additionally, it can induce migraines and gastrointestinal injury and is used to study increased intracranial pressure secondary to severe traumatic brain injury in adults, as well as rheumatoid arthritis. It can also be used to induce gastric ulcer models.

Indomethacin sodium hydrate

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Purity: 99.45%

Catalog No. T22346Alias Indometacin sodium hydrateCas No. 74252-25-8

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$40	-	In Stock
1 g	$48	-	In Stock
1 mL x 10 mM (in DMSO)	$39	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.45%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Indomethacin sodium hydrate is an effective orally active, competitive, and reversible inhibitor of COX-1 and COX-2, with IC50 values of 18 nM and 26 nM, respectively. It possesses anti-inflammatory, anticancer, and antimicrobial activities and is commonly used in research related to cancer, inflammation, and viral infections. Additionally, it can induce migraines and gastrointestinal injury and is used to study increased intracranial pressure secondary to severe traumatic brain injury in adults, as well as rheumatoid arthritis. It can also be used to induce gastric ulcer models.
In vitro	In 3LL-D122 cells, Indomethacin sodium hydrate (0, 20, 50, 100, and 150 μM; 24 hours) inhibited cell viability, with inhibition observed at 20 mM and 50% inhibition at 60 mM[2].
In vivo	In male Sprague-Dawley rats, Indomethacin sodium hydrate (0.01-10 mg/kg; oral administration; for 3 hours) inhibited carrageenan-induced paw edema and hyperalgesia in a dose-dependent manner, with an ED50 of 2.0 mg/kg for paw edema and 1.5 mg/kg for hyperalgesia[1].
Synonyms	Indometacin sodium hydrate

Chemical Properties

Molecular Weight	433.82
Formula	C₁₉H₂₁ClNNaO₇
Cas No.	74252-25-8
Smiles	O=C([O-])CC1=C(N(C2=C1C=C(OC)C=C2)C(C3=CC=C(Cl)C=C3)=O)C.[Na+].O.O.O
Relative Density.	no data available

Storage & Solubility Information

Storage

store under nitrogen,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5 mg/mL (11.53 mM), Sonification is recommended.

H2O: 20 mg/mL (46.1 mM), Sonification is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.31 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.3051 mL	11.5255 mL	23.0510 mL	115.2552 mL
5 mM	0.4610 mL	2.3051 mL	4.6102 mL	23.0510 mL
10 mM	0.2305 mL	1.1526 mL	2.3051 mL	11.5255 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.1153 mL	0.5763 mL	1.1526 mL	5.7628 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc