Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CYP121A1-IN-1 is a potent inhibitor of CYP121A1, demonstrating favorable activity against Mycobacterium tuberculosis (H37Rv MIC 90 ~6.25 μM, ~2.2 μg/mL). It significantly reduces mycocyclosin production by blocking the CYP121A1-mediated conversion of cyclo(l-tyrosyl-l-tyrosyl) to mycocyclosin [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,520.00 | |
50 mg | 10-14 weeks | $ 1,980.00 | |
100 mg | 10-14 weeks | $ 2,500.00 |
Description | CYP121A1-IN-1 is a potent inhibitor of CYP121A1, demonstrating favorable activity against Mycobacterium tuberculosis (H37Rv MIC 90 ~6.25 μM, ~2.2 μg/mL). It significantly reduces mycocyclosin production by blocking the CYP121A1-mediated conversion of cyclo(l-tyrosyl-l-tyrosyl) to mycocyclosin [1]. |
In vitro | CYP121A1-IN-1 (compound 61), used in concentrations ranging from 0.78 to 400 μM for durations of either one week (c7H9 and 7H9-Low BSA media) or two weeks (MMM-Ch medium), exhibits effective activity against the Mtb strain H37Rv, with a MIC 90 of approximately 6.25 μM (about 2.2 μg/mL) [1]. |
Molecular Weight | 356.42 |
Formula | C22H20N4O |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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CYP121A1-IN-1 inhibitor inhibit