Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BRD4 Inhibitor-20 is a potent bromodomain protein 4 (BRD4) inhibitor with oral activity. BRD4 Inhibitor-20 has antiproliferative activity in cancer cell lines and is used in studies of various cancers, such as colon cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 64.00 | |
5 mg | In stock | $ 155.00 | |
10 mg | In stock | $ 255.00 | |
25 mg | In stock | $ 513.00 | |
50 mg | In stock | $ 747.00 | |
100 mg | In stock | $ 1,050.00 | |
500 mg | In stock | $ 2,080.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 195.00 |
Description | BRD4 Inhibitor-20 is a potent bromodomain protein 4 (BRD4) inhibitor with oral activity. BRD4 Inhibitor-20 has antiproliferative activity in cancer cell lines and is used in studies of various cancers, such as colon cancer. |
Targets&IC50 | BRD4 BD2:28 nM, BRD4 BD1:19 nM |
In vitro | BRD4 Inhibitor-20 has inhibitory activity for BRD4 (BD1) and BRD4 (BD2) with IC50 values of 19 nM and 28 nM, respectively. BRD4 Inhibitor-20 has anti-proliferation potency with IC50 values of 4.75 μM, 1.35 μM and 44.07 μM in HT-29, HL-60 and WI-38 cells, respectively[1]. |
In vivo | Oral BRD4 Inhibitor -20, 15mg/kg showed good oral pharmacokinetic characteristics[1]. |
Molecular Weight | 358.41 |
Formula | C18H18N2O4S |
CAS No. | 2490311-14-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (83.7 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BRD4 Inhibitor-20 2490311-14-1 Chromatin/Epigenetic Epigenetic Reader Domain inhibitor inhibit