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BRD4 Inhibitor-20

Name: BRD4 Inhibitor-20
Brand: TargetMol
SKU: T61318
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61318Cas No. 2490311-14-1

BRD4 Inhibitor-20 is a potent bromodomain protein 4 (BRD4) inhibitor with oral activity, demonstrating antiproliferative effects in cancer cell lines and used in studies of various cancers, including colon cancer.

BRD4 Inhibitor-20

🥰Excellent

Purity: 99.84%

Catalog No. T61318Cas No. 2490311-14-1

Pack Size	Price	Availability
2 mg	$33	In Stock
5 mg	$56	In Stock
10 mg	$92	In Stock
25 mg	$178	In Stock
50 mg	$269	In Stock
100 mg	$378	In Stock
200 mg	$513	In Stock
1 mL x 10 mM (in DMSO)	$70	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.84%

Resource Download

COA HNMR LCMS HPLC

Product Introduction

Bioactivity

Description	BRD4 Inhibitor-20 is a potent bromodomain protein 4 (BRD4) inhibitor with oral activity, demonstrating antiproliferative effects in cancer cell lines and used in studies of various cancers, including colon cancer.
Targets&IC50	BRD4 BD1:19 nM, BRD4 BD2:28 nM, BRD2 (BD2):18 nM, BRD2 (BD1):24 nM
In vitro	BRD4 Inhibitor-20 has inhibitory activity for BRD4 (BD1) and BRD4 (BD2) with IC50 values of 19 nM and 28 nM, respectively. BRD4 Inhibitor-20 has anti-proliferation potency with IC50 values of 4.75 μM, 1.35 μM and 44.07 μM in HT-29, HL-60 and WI-38 cells, respectively[1].
In vivo	Oral BRD4 Inhibitor -20, 15mg/kg showed good oral pharmacokinetic characteristics[1].

Chemical Properties

Molecular Weight	358.41
Formula	C₁₈H₁₈N₂O₄S
Cas No.	2490311-14-1
Smiles	C(C)(C)=C1C=2C(NC1=O)=CC=C(NS(=O)(=O)C3=C(OC)C=CC=C3)C2
Color	Red
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (83.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7901 mL	13.9505 mL	27.9010 mL	139.5050 mL
5 mM	0.5580 mL	2.7901 mL	5.5802 mL	27.9010 mL
10 mM	0.2790 mL	1.3951 mL	2.7901 mL	13.9505 mL
20 mM	0.1395 mL	0.6975 mL	1.3951 mL	6.9753 mL
50 mM	0.0558 mL	0.2790 mL	0.5580 mL	2.7901 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc