Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tafamidis meglumine (Fx-1006A) is a Potent and Selective Transthyretin Kinetic Stabilizer That Inhibits the Amyloid Cascade
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 47.00 | |
10 mg | In stock | $ 80.00 | |
25 mg | In stock | $ 155.00 | |
50 mg | In stock | $ 239.00 | |
100 mg | In stock | $ 369.00 | |
500 mg | In stock | $ 869.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 52.00 |
Description | Tafamidis meglumine (Fx-1006A) is a Potent and Selective Transthyretin Kinetic Stabilizer That Inhibits the Amyloid Cascade |
Targets&IC50 | TTR:2.7-3.2 μM (EC50) |
In vitro | Tafamidis binds selectively and with negative cooperativity (K(d)s ~2 nM and ~200 nM) to the two normally unoccupied thyroxine-binding sites of the tetramer, and kinetically stabilizes TTR.?Patient-derived amyloidogenic variants of TTR, including kinetically and thermodynamically less stable mutants, are also stabilized by tafamidis binding[1]. |
Synonyms | Fx-1006A |
Molecular Weight | 503.33 |
Formula | C21H24Cl2N2O8 |
CAS No. | 951395-08-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12.5 mg/mL (24.83 mM)
You can also refer to dose conversion for different animals. More
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tafamidis meglumine 951395-08-7 Others Fx-1006A Inhibitor Tafamidis inhibit inhibitor