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Lalistat 1

Name: Lalistat 1
Brand: TargetMol
SKU: T38344
Price: 217 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38344Cas No. 501104-16-1

Alias ZINC795230

Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL, IC50 = 68 nM) and IgA1 protease for H. influenzae. Lalistat 1 can be used in studies about niemann-pick type C diseases.

Lalistat 1

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Purity: 99.87%

Catalog No. T38344Alias ZINC795230Cas No. 501104-16-1

Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL, IC50 = 68 nM) and IgA1 protease for H. influenzae. Lalistat 1 can be used in studies about niemann-pick type C diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$46	-	In Stock
10 mg	$63	-	In Stock
25 mg	$98	-	In Stock
50 mg	$148	-	In Stock
100 mg	$217	-	In Stock
500 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.87%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL, IC50 = 68 nM) and IgA1 protease for H. influenzae. Lalistat 1 can be used in studies about niemann-pick type C diseases.
Targets&IC50	LAL (human):68 nM (IC50)
In vitro	Lalistat 1 (0-100 μM) inhibits IgA1P B1 and B2 dose-dependently, achieving near-complete inhibition at 50 μM and complete inhibition at 100 μM [1]. Additionally, Lalistat 1 reduces cholesterol accumulation in lysosome-like reservoirs of GM03123 human fibroblasts lacking NPC1 [2].
Synonyms	ZINC795230

Chemical Properties

Molecular Weight	298.36
Formula	C₁₂H₁₈N₄O₃S
Cas No.	501104-16-1
Smiles	O=C(Oc1nsnc1N1CCCCC1)N1CCOCC1
Relative Density.	1.356 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 20 mg/mL (67.03 mM), Sonication is recommended.

DMSO: 45 mg/mL (150.82 mM), Sonication is recommended.

DMF: 20 mg/mL (67.03 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3517 mL	16.7583 mL	33.5166 mL	167.5828 mL
5 mM	0.6703 mL	3.3517 mL	6.7033 mL	33.5166 mL
10 mM	0.3352 mL	1.6758 mL	3.3517 mL	16.7583 mL
20 mM	0.1676 mL	0.8379 mL	1.6758 mL	8.3791 mL
50 mM	0.0670 mL	0.3352 mL	0.6703 mL	3.3517 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc