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HDAC6-IN-5

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Catalog No. T62046Cas No. 2413603-15-1

HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated inhibitor of HDAC6 (IC50 = 0.025 μM) that inhibits Aβ 1-42 self-aggregation and AChE with IC50 values of 3.0 and 0.72 μM, respectively. Additionally, HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity.

HDAC6-IN-5

HDAC6-IN-5

😃Good
Catalog No. T62046Cas No. 2413603-15-1
HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated inhibitor of HDAC6 (IC50 = 0.025 μM) that inhibits Aβ 1-42 self-aggregation and AChE with IC50 values of 3.0 and 0.72 μM, respectively. Additionally, HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,5206-8 weeks6-8 weeks
50 mg$1,9806-8 weeks6-8 weeks
100 mg$2,5006-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated inhibitor of HDAC6 (IC50 = 0.025 μM) that inhibits Aβ 1-42 self-aggregation and AChE with IC50 values of 3.0 and 0.72 μM, respectively. Additionally, HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity.
Targets&IC50
HDAC6:0.026 ± 0. μM, HDAC9:5.51 ± 0.0 μM, HDAC7:9.13 ± 0.3 μM, HDAC1:0.09 ± 0.0 μM, AChE:0.72 μM, HDAC4:7.85 ± 0.6 μM, HDAC:0.16 ± 0.0 μM, HDAC2:0.48 ± 0.0 μM, HDAC5:7.19 ± 0.4 μM, HDAC3:0.33 ± 0. μM
In vitro
HDAC6-IN-5 (compound 11b) effectively promotes the acetylation of histone H3 and α-tubulin in a dose-dependent manner, with half-maximal effects (EC50 values) at 0.58 μM for histone H3 and 8 μM for α-tubulin, respectively [1].
Chemical Properties
Molecular Weight408.25
FormulaC20H14BrN3O2
Cas No.2413603-15-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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