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5Z-7-Oxozeaenol

Name: 5Z-7-Oxozeaenol
Brand: TargetMol
SKU: T14055
Rating: 4.5 (1 reviews)

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Catalog No. T14055Cas No. 253863-19-3

Alias LL-Z 1640-2, L783279, FR148083

5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK1 and low activity against MEK1 with IC50 of 411 nM, it is also an inhibitor of VEGF-R2 with IC50 of 52 nM.

5Z-7-Oxozeaenol

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Purity: 99%

Catalog No. T14055Alias LL-Z 1640-2, L783279, FR148083Cas No. 253863-19-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$326	35 days	35 days
5 mg	$733	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99%

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Product Introduction

Bioactivity

Description	5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK1 and low activity against MEK1 with IC50 of 411 nM, it is also an inhibitor of VEGF-R2 with IC50 of 52 nM.
Targets&IC50	VEGFR2:52 nM, PDGFRβ:340 nM, VEGFR3:110 nM, MEK1:411 nM, B-Raf (VE):6300 nM, TAK1:8.1 nM, FLT3:170 nM, Src:6600 nM
In vitro	5Z-7-Oxozeaenol is a natural anti-protozoan compound from the fungal origin with inhibitory activity against VEGF-R3, FLT3, PDGFR-β, B-RAF VE, and SRC with IC50s of 110, 170, 340, 6300, and 6600 nM, respectively[1]. 5Z-7-Oxozaeenol inhibited PMA-induced AP-1 activity to almost basal levels in KT cells but had no effect on IL-1-induced NF-kB activity in KK cells[2]. 5Z-7-Oxozaeenol inhibits the JNK/p38 pathway, but it is not a direct inhibitor and is signal-specific. 5Z-7-Oxozaeenol prevents inflammation by inhibiting the catalytic activity of the TAK1 MAPK kinase[3].
Synonyms	LL-Z 1640-2, L783279, FR148083

Chemical Properties

Molecular Weight	362.37
Formula	C₁₉H₂₂O₇
Cas No.	253863-19-3
Smiles	COc1cc(O)c2c(c1)\C=C\C[C@H](O)[C@H](O)C(=O)\C=C/C[C@H](C)OC2=O
Relative Density.	1.270 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (110.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (5.52 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7596 mL	13.7981 mL	27.5961 mL	137.9805 mL
5 mM	0.5519 mL	2.7596 mL	5.5192 mL	27.5961 mL
10 mM	0.2760 mL	1.3798 mL	2.7596 mL	13.7981 mL
20 mM	0.1380 mL	0.6899 mL	1.3798 mL	6.8990 mL
50 mM	0.0552 mL	0.2760 mL	0.5519 mL	2.7596 mL
100 mM	0.0276 mL	0.1380 mL	0.2760 mL	1.3798 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc