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Dbet57

Name: Dbet57
Brand: TargetMol
SKU: T5440
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5440Cas No. 1883863-52-2

dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50/5h of 500 nM ,and inactive on BRD4BD2

Dbet57

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Purity: 99.52%

Catalog No. T5440Cas No. 1883863-52-2

dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50/5h of 500 nM ,and inactive on BRD4BD2

Pack Size	Price	Availability
1 mg	$42	In Stock
5 mg	$98	In Stock
10 mg	$158	In Stock
25 mg	$293	In Stock
50 mg	$455	In Stock
100 mg	$658	In Stock
500 mg	$1,360	In Stock
1 mL x 10 mM (in DMSO)	$178	In Stock

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Batch Information

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Purity:99.52%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50/5h of 500 nM ,and inactive on BRD4BD2
Targets&IC50	BRD4 BD1:500 nM (DC50)

Chemical Properties

Molecular Weight	699.18
Formula	C₃₄H₃₁ClN₈O₅S
Cas No.	1883863-52-2
Smiles	CC=1C2=C(N3C([C@H](CC(NCCNC4=C5C(C(=O)N(C5=O)C6C(=O)NC(=O)CC6)=CC=C4)=O)N=C2C7=CC=C(Cl)C=C7)=NN=C3C)SC1C
Relative Density.	1.60 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (357.56 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (7.15 mM)

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4302 mL	7.1512 mL	14.3025 mL	71.5123 mL
5 mM	0.2860 mL	1.4302 mL	2.8605 mL	14.3025 mL
10 mM	0.1430 mL	0.7151 mL	1.4302 mL	7.1512 mL
20 mM	0.0715 mL	0.3576 mL	0.7151 mL	3.5756 mL
50 mM	0.0286 mL	0.1430 mL	0.2860 mL	1.4302 mL
100 mM	0.0143 mL	0.0715 mL	0.1430 mL	0.7151 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc