Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SR-717 free acid is a stable cGAMP mimetic and a non-nucleotide STING agonist. It exhibits antitumor activity with EC50 values of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively.
Pack Size | Availability | Price/USD | Quantity |
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5 mg | Inquiry | $ 970.00 |
Description | SR-717 free acid is a stable cGAMP mimetic and a non-nucleotide STING agonist. It exhibits antitumor activity with EC50 values of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. |
In vitro | SR-717 functions as a STING activator, triggering a closed conformation that opens pathways for investigating its role as a systemic STING agonist across various contexts, including enhancing antitumor immunity. Specifically, at a concentration of 3.8 μM, SR-717 promotes PD-L1 expression in both THP1 cells and primary human peripheral blood mononuclear cells, dependent on the STING pathway. |
In vivo | SR-717, administered at a dosage of 30 mg/kg intraperitoneally once per day for one week, exhibits antitumor activities in both WT or Sting gt/gt mice [1]. This compound not only demonstrates significant antitumor activity, but also enhances the activation of CD8+ T cells, natural killer cells, and dendritic cells within pertinent tissues, aiding in antigen cross-priming. The administration of SR-717 under the specified conditions resulted in the maximal inhibition of tumor growth, underscoring its potential therapeutic efficacy in cancer models [1]. |
Molecular Weight | 345.266 |
Formula | C15H9F2N5O3 |
CAS No. | 2375420-34-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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