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GSK J5
🥰Excellent
Catalog No. T22821Cas No. 1394854-51-3
Alias GSK-J5, GSKJ5
GSK J5 is an inhibitor of schistosomes and helminths and is often used as a trematode insecticide.GSK J5 promotes schistosome mortality in a dose- and time-dependent manner.GSK J5 increases the mortality rate of schistosomes and decreases the viability of adult worms.GSK J5 is an inhibitor of schistosomes and helminths and is often used as a trematode insecticide.
GSK J5
🥰Excellent
Purity: 99.81%
Catalog No. T22821Alias GSK-J5, GSKJ5Cas No. 1394854-51-3
GSK J5 is an inhibitor of schistosomes and helminths and is often used as a trematode insecticide.GSK J5 promotes schistosome mortality in a dose- and time-dependent manner.GSK J5 increases the mortality rate of schistosomes and decreases the viability of adult worms.GSK J5 is an inhibitor of schistosomes and helminths and is often used as a trematode insecticide.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $39 | In Stock | |
| 5 mg | $128 | In Stock | |
| 10 mg | $213 | In Stock | |
| 25 mg | $472 | In Stock | |
| 50 mg | $689 | In Stock | |
| 100 mg | $983 | In Stock | |
| 500 mg | $1,970 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $119 | In Stock |
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Purity:99.81%
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Product Introduction
Bioactivity
Chemical Properties
| Description | GSK J5 is an inhibitor of schistosomes and helminths and is often used as a trematode insecticide.GSK J5 promotes schistosome mortality in a dose- and time-dependent manner.GSK J5 increases the mortality rate of schistosomes and decreases the viability of adult worms.GSK J5 is an inhibitor of schistosomes and helminths and is often used as a trematode insecticide. |
| In vitro | GSK J5 (30 μM; 24-96 h) inhibits schistosomes, (5 and 20 μM; 24 h) also inhibits helminths and promotes small changes in worm motility.[1] |
| In vivo | It is worth noting that the injection of GSK-J4 attenuated disease progression in a human AML xenograft mouse model. Treatment with GSK-J4 mainly resulted in the downregulation of DNA replication and cell cycle-related pathways and prevents the expression of HOX, a key cancer gene. ChIP-qPCR verified the increased H3K27me3 enrichment in the HOX gene transcription initiation site [1]. |
| Synonyms | GSK-J5, GSKJ5 |
| Molecular Weight | 417.5 |
| Formula | C24H27N5O2 |
| Cas No. | 1394854-51-3 |
| Smiles | N(CCC(OCC)=O)C1=CC(=NC(=N1)C=2C=CC=NC2)N3CCC=4C(CC3)=CC=CC4 |
| Relative Density. | 1.216 g/cm3 (Predicted) |
| Color | Yellow |
| Appearance | Oil |
Storage & Solubility Information
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.18 mg/mL (10.01 mM), Sonication is recommended. Ethanol: < 41.75 mg/mL, Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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