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Ro 5212773

Name: Ro 5212773
Brand: TargetMol
SKU: T9357
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9357Cas No. 1110781-88-8

Alias Epptb

Ro 5212773 (Epptb) is a selective TAAR1 antagonist.

Ro 5212773

🥰Excellent

Purity: 99.61%

Catalog No. T9357Alias EpptbCas No. 1110781-88-8

Ro 5212773 (Epptb) is a selective TAAR1 antagonist.

Pack Size	Price	Availability
1 mg	$31	In Stock
5 mg	$72	In Stock
10 mg	$128	In Stock
25 mg	$285	In Stock
50 mg	$570	In Stock
100 mg	$817	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock

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Batch Information

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Purity:99.61%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Ro 5212773 (Epptb) is a selective TAAR1 antagonist.
Targets&IC50	TAAR1:28 nM
In vivo	EPPTB prevents the reduction of the firing frequency of DA neurons induced by p-tyramine (p-tyr), a nonselective TAAR1 agonist. the EPPTB effects were absent in Taar1 knockout mice, ruling out off-target effects[2].
Synonyms	Epptb

Chemical Properties

Molecular Weight	378.39
Formula	C₂₀H₂₁F₃N₂O₂
Cas No.	1110781-88-8
Smiles	CCOc1cccc(NC(=O)c2ccc(N3CCCC3)c(c2)C(F)(F)F)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 55 mg/mL (145.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6428 mL	13.2139 mL	26.4278 mL	132.1388 mL
5 mM	0.5286 mL	2.6428 mL	5.2856 mL	26.4278 mL
10 mM	0.2643 mL	1.3214 mL	2.6428 mL	13.2139 mL
20 mM	0.1321 mL	0.6607 mL	1.3214 mL	6.6069 mL
50 mM	0.0529 mL	0.2643 mL	0.5286 mL	2.6428 mL
100 mM	0.0264 mL	0.1321 mL	0.2643 mL	1.3214 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc