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Anti-Caspase-3 Antibody (4L394)
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Catalog No. TMAH-00141
Alias Yama, SCA-1, CPP32B, CPP32, apopain
Anti-Caspase-3 Antibody (4L394) is an antibody targeting Caspase-3. Anti-Caspase-3 Antibody (4L394) can be used in ELISA, WB, IHC.
Anti-Caspase-3 Antibody (4L394)
Anti-Caspase-3 Antibody (4L394)
😃Good
Catalog No. TMAH-00141Alias Yama, SCA-1, CPP32B, CPP32, apopain
Anti-Caspase-3 Antibody (4L394) is an antibody targeting Caspase-3. Anti-Caspase-3 Antibody (4L394) can be used in ELISA, WB, IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $209 | 7-10 days | |
| 100 μL | $348 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Rabbit Monoclonal Application: ELISA, WB, IHC Reactivity: Human |
| Alias | Yama, SCA-1, CPP32B, CPP32, apopain |
| Ig Type | Rabbit IgG |
| Clone | 4L394 |
| Reactivity | Human |
| Verified Activity | 1. Western Blot -Positive WB detected in: Hela whole cell lysate, HEK293 whole cell lysate, Ntera-2 cell lysate -All lanes: CASP3 antibody at 1:1000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 32 kDa -Observed band size: 32, 55, 130 kDa 2. IHC image of TMAH-00141 diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| Application | ELISA, WB, IHC |
| Recommended Dose | WB:1:500-1:5000; IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress. Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human active + pro Caspase 3 |
| Antigen Species | Human |
| Gene ID | 836 |
| Uniprot ID | |
| Biology Area | Cancer, Cell biology, Metabolism |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Sci Citations
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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