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Podocarpusflavone A

Name: Podocarpusflavone A
Brand: TargetMol
SKU: TQ0134
Price: 81 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0134Cas No. 22136-74-9

Podocarpusflavone A is a DNA topoisomerase I inhibitor with moderate anti-proliferative activity that induces cell apoptosis in MCF-7.

Podocarpusflavone A

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Purity: 99.89%

Catalog No. TQ0134Cas No. 22136-74-9

Podocarpusflavone A is a DNA topoisomerase I inhibitor with moderate anti-proliferative activity that induces cell apoptosis in MCF-7.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$81	-	In Stock
5 mg	$198	In Stock	In Stock
10 mg	$297	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.89%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Podocarpusflavone A is a DNA topoisomerase I inhibitor with moderate anti-proliferative activity that induces cell apoptosis in MCF-7.
Targets&IC50	FASN:24.08, Topo I:119.425 μM (IC50)
In vitro	Podocarpusflavone A showed significant inhibition against KB, DLD, HEp-2, MCF-7 tumour cell lines (ED50 4.56-16.24 μg/mL). It induced cell apoptosis in MCF-7 mainly via sub-G1/S phase arrest. PF (40 ug/mL, 24 hours) induced a significant increase in cell death and growth arrest in the S phase by about 10-fold compared to the control group;[1]Podocarpusflavone A (0,5,10,20 μM) treatment of four melanoma cell lines (A375, Malme-3M, SK-MEL-1, and SK-MEL5) for 24 h significantly inhibited p-STAT3 levels, but not total STAT3 protein levels, in all cell lines tested. In addition, a dose-dependent inhibition of p-STAT3 expression was observed in both A375 and SK-MEL-1 cells and the IC50 values were approximately 10 μM for both A375 and SK-MEL-1 cells.[2]
In vivo	Podocarpusflavone A was administered daily to A375 cell-derived xenograft mice (20, 40 mg/kg, po, for 21 days), and Podocarpusflavone A significantly suppressed tumor size and weight in xenograft mice. [2]

Chemical Properties

Molecular Weight	552.48
Formula	C₃₁H₂₀O₁₀
Cas No.	22136-74-9
Smiles	COc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)c(-c3cc(ccc3O)-c3cc(=O)c4c(O)cc(O)cc4o3)c2o1
Relative Density.	1.576 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (72.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8100 mL	9.0501 mL	18.1002 mL	90.5010 mL
5 mM	0.3620 mL	1.8100 mL	3.6200 mL	18.1002 mL
10 mM	0.1810 mL	0.9050 mL	1.8100 mL	9.0501 mL
20 mM	0.0905 mL	0.4525 mL	0.9050 mL	4.5251 mL
50 mM	0.0362 mL	0.1810 mL	0.3620 mL	1.8100 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc