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NSC-70220

Name: NSC-70220
Brand: TargetMol
SKU: T12978
Rating: 4.5 (1 reviews)

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Catalog No. T12978Cas No. 4551-00-2

Alias SOS1-IN-1

SOS1-IN-1 is an inhibitor of SOS1.

NSC-70220

😃Good

Catalog No. T12978Alias SOS1-IN-1Cas No. 4551-00-2

SOS1-IN-1 is an inhibitor of SOS1.

Pack Size	Price	Availability
2 mg	$242	5 days
5 mg	$297	5 days
25 mg	$987	6-8 weeks
50 mg	$1,360	6-8 weeks
100 mg	$1,860	6-8 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	SOS1-IN-1 is an inhibitor of SOS1.
In vitro	SOS1-IN-1 (40 μM) and NSC-658497(30 μM) result in growth inhibitory rate of 29% and 8% respectively. The combination treatment results in growth inhibitory rate of 54%, showing the synergistic effect of SOS1-IN-1 and NSC-658497 on cell growth inhibition. It is showed that the treatment with NSC-658497 at 40 μM for 2 hours alone or in combìnation with the treatment with 40 μM of SOS1-IN-1 overnight resulted in lower expression levels of P-AKT and P-ERK. The treatment wlth 40 μM of SOS1-IN-1 overnight resulted in lower expression levels of P-ERK.
Synonyms	SOS1-IN-1

Chemical Properties

Molecular Weight	325.36
Formula	C₂₂H₁₅NO₂
Cas No.	4551-00-2
Relative Density.	1.321 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 12.5 mg/mL (38.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0735 mL	15.3676 mL	30.7352 mL	153.6759 mL
5 mM	0.6147 mL	3.0735 mL	6.1470 mL	30.7352 mL
10 mM	0.3074 mL	1.5368 mL	3.0735 mL	15.3676 mL
20 mM	0.1537 mL	0.7684 mL	1.5368 mL	7.6838 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc