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YLF-466D

Name: YLF-466D
Brand: TargetMol
SKU: T13368
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13368Cas No. 1273323-67-3

Alias C24

YLF-466D (C24) is a novel AMPK activator that inhibits platelet aggregation.

YLF-466D

🥰Excellent

Purity: 97.74%

Catalog No. T13368Alias C24Cas No. 1273323-67-3

YLF-466D (C24) is a novel AMPK activator that inhibits platelet aggregation.

Pack Size	Price	Availability
1 mg	$31	In Stock
5 mg	$76	In Stock
10 mg	$119	In Stock
25 mg	$209	In Stock
50 mg	$298	In Stock
100 mg	$413	In Stock
200 mg	$568	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock

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Purity:97.74%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	YLF-466D (C24) is a novel AMPK activator that inhibits platelet aggregation.
In vitro	The study investigates the impact of YLF-466D on platelet AMPK activation and its potential to inhibit platelet aggregation. Activation of platelet AMPK by YLF-466D is confirmed through phosphorylation at Thr172, leading to the suppression of platelet aggregation triggered by thrombin, ADP, and collagen. This demonstrates that YLF-466D's anti-aggregatory effect is broad and not specific to the type of platelet agonist. The effects of YLF-466D on AMPK activation and aggregation inhibition are concentration-dependent, showing maximal effectiveness at 150 μM. The IC50 values for inhibiting aggregation induced by thrombin, ADP, and collagen are approximately 84, 55, and 87 μM, respectively.
Synonyms	C24

Chemical Properties

Molecular Weight	465.93
Formula	C₂₉H₂₀ClNO₃
Cas No.	1273323-67-3
Smiles	OC(=O)c1cccc(CN2C(=O)\C(=C(/c3ccccc3)c3ccc(Cl)cc3)c3ccccc23)c1
Relative Density.	1.358 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (193.16 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1462 mL	10.7312 mL	21.4625 mL	107.3123 mL
5 mM	0.4292 mL	2.1462 mL	4.2925 mL	21.4625 mL
10 mM	0.2146 mL	1.0731 mL	2.1462 mL	10.7312 mL
20 mM	0.1073 mL	0.5366 mL	1.0731 mL	5.3656 mL
50 mM	0.0429 mL	0.2146 mL	0.4292 mL	2.1462 mL
100 mM	0.0215 mL	0.1073 mL	0.2146 mL	1.0731 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc