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Aceclidine

Name: Aceclidine
Brand: TargetMol
SKU: T19870
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19870Cas No. 827-61-2

Alias Quinuclidin-3-yl acetate, NSC-657843, NSC657843, NSC 657843, Glaucostat, 3-quinuclidinyl acetate, 3-Acetoxyquinuclidine, 1-azabicyclo[2.2.2]octan-3-yl acetate

Aceclidine (1-azabicyclo[2.2.2]octan-3-yl acetate) is a modulator of M3 mAChR and can be used in studies about treating glaucoma by reducing intraocular pressure.

Aceclidine

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Catalog No. T19870Alias Quinuclidin-3-yl acetate, NSC-657843, NSC657843, NSC 657843, Glaucostat, 3-quinuclidinyl acetate, 3-Acetoxyquinuclidine, 1-azabicyclo[2.2.2]octan-3-yl acetateCas No. 827-61-2

Aceclidine (1-azabicyclo[2.2.2]octan-3-yl acetate) is a modulator of M3 mAChR and can be used in studies about treating glaucoma by reducing intraocular pressure.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	-	In Stock
500 mg	$52	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:>99.99%

Appearance:Viscous

Color:White

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Product Introduction

Aceclidine AI Summary

Aceclidine exhibits a range of bioactivities primarily targeting muscarinic acetylcholine receptors and phosphoinositol metabolism. It demonstrates strong binding affinity to the muscarinic acetylcholine receptor M1, with an IC50 of 120 nM using [3H]oxotremorine-M radioligand in rat hippocampus membranes, and a lower binding affinity (IC50 of 2427 nM) with [3H]pirenzepine radioligand. At 100 µM, it stimulates phosphoinositol (PI) hydrolysis by 60.5% in A9 L cells transfected with M1 receptors, with an EC50 of 4466 nM. Additionally, it induces marked salivation or tremor in mice at a dose of 10 mg/kg (Score = 2.0). The compound also shows significant inhibition of [3H](R)-QNB binding to muscarinic receptors in rat brain membranes (IC50 of 510 nM) and an 80% agonist activity in PI metabolism assays in rat cerebral cortex slices. Against muscarinic receptor M3 in A9 L cells, it has an EC50 of 10000 nM and a maximum stimulation of 130%. Moreover, it demonstrates binding affinities with a Ki value of 16 nM for [3H]OXO-M in rat brain membranes and exhibits phosphoinositol stimulation responses of up to 300% in rat hippocampal slices with an EC50 of 21000 nM. Additionally, Aceclidine shows antiviral activity against SARS-CoV-2, inhibiting cytotoxicity of VERO-6 cells at moderate concentrations, with varied IC50 values greater than 19952.62 nM. In other assays, it inhibits SARS-CoV-2 3CL-Pro protease by approximately 31.5% at 20 µM. The compound has inhibitory effects on the malarial parasite plastid (IC50 = 4775.5 nM) and RGS4 (IC50 = 42.3 nM), and displays growth inhibition in various human tumor cell lines, with notable potency against the A498 Renal cell line (GI50 = 3451.44 nM). Furthermore, it shows bioactivity related to toxicity in Musca domestica and affinity for muscarinic acetylcholine receptors in Drosophila melanogaster..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Aceclidine (1-azabicyclo[2.2.2]octan-3-yl acetate) is a modulator of M3 mAChR and can be used in studies about treating glaucoma by reducing intraocular pressure.
Synonyms	Quinuclidin-3-yl acetate, NSC-657843, NSC657843, NSC 657843, Glaucostat, 3-quinuclidinyl acetate, 3-Acetoxyquinuclidine, 1-azabicyclo[2.2.2]octan-3-yl acetate

Chemical Properties

Molecular Weight	169.22
Formula	C₉H₁₅NO₂
Cas No.	827-61-2
Smiles	CC(=O)OC1CN2CCC1CC2
Relative Density.	1.0873 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 10 mg/mL (59.09 mM), Sonication is recommended.

DMSO: Soluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	5.9095 mL	29.5473 mL	59.0947 mL	295.4733 mL
5 mM	1.1819 mL	5.9095 mL	11.8189 mL	59.0947 mL
10 mM	0.5909 mL	2.9547 mL	5.9095 mL	29.5473 mL
20 mM	0.2955 mL	1.4774 mL	2.9547 mL	14.7737 mL
50 mM	0.1182 mL	0.5909 mL	1.1819 mL	5.9095 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc