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15(S)-HETrE

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Catalog No. T37400Cas No. 92693-02-2

15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-γ-linolenic acid. It inhibits 5-LO in human PMNL with an IC50 value of 4.6 μM. In RBL cells, 15(S)-HETrE also inhibits 5-LO, but is approximately 1/20 as potent as 15(S)-HpETE.

15(S)-HETrE
Other Forms of 15(S)-HETrE:

15(S)-HETrE

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Catalog No. T37400Cas No. 92693-02-2
15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-γ-linolenic acid. It inhibits 5-LO in human PMNL with an IC50 value of 4.6 μM. In RBL cells, 15(S)-HETrE also inhibits 5-LO, but is approximately 1/20 as potent as 15(S)-HpETE.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μg$28735 days35 days
50 μg$54335 days35 days
100 μg$99335 days35 days
500 μg$2,23035 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-γ-linolenic acid. It inhibits 5-LO in human PMNL with an IC50 value of 4.6 μM. In RBL cells, 15(S)-HETrE also inhibits 5-LO, but is approximately 1/20 as potent as 15(S)-HpETE.
Chemical Properties
Molecular Weight322.48
FormulaC20H34O3
Cas No.92693-02-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
0.1 M Na2CO3: 2 mg/mL (6.2 mM), Sonication is recommended.
Ethanol: Miscible
DMF: Miscible
PBS (pH 7.2): 0.8 mg/mL (2.48 mM), Sonication is recommended.
DMSO: Miscible
Solution Preparation Table
PBS (pH 7.2)/0.1 M Na2CO3
1mg5mg10mg50mg
1 mM3.1010 mL15.5048 mL31.0097 mL155.0484 mL
0.1 M Na2CO3
1mg5mg10mg50mg
5 mM0.6202 mL3.1010 mL6.2019 mL31.0097 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

15(S) HETrE15(S)HETrE15HETrE
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