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G6PD activator AG1

Name: G6PD activator AG1
Brand: TargetMol
SKU: T11347
Price: 196 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11347Cas No. 421581-52-4

G6PD activator AG1 is a glucose-6-phosphate dehydrogenase (G6PD) agonist that promotes glucose-6-phosphate dehydrogenase (G6PD) oligomerization to a catalytically competent form. G6PD activator AG1 reduces oxidative stress in cells and zebrafish, reduces chloroquine or diamide-induced oxidative stress in human erythrocytes, and can be used to study glucose-6-phosphate dehydrogenase deficiency.

G6PD activator AG1

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Purity: 99.51%

Catalog No. T11347Cas No. 421581-52-4

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$196	In Stock	In Stock
5 mg	$280	In Stock	In Stock
10 mg	$380	-	In Stock
25 mg	$637	-	In Stock
50 mg	$911	-	In Stock
100 mg	$1,460	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.51%

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	G6PD activator AG1 is a glucose-6-phosphate dehydrogenase (G6PD) agonist that promotes glucose-6-phosphate dehydrogenase (G6PD) oligomerization to a catalytically competent form. G6PD activator AG1 reduces oxidative stress in cells and zebrafish, reduces chloroquine or diamide-induced oxidative stress in human erythrocytes, and can be used to study glucose-6-phosphate dehydrogenase deficiency.
Targets&IC50	G6PD:3 µΜ
In vitro	G6PD activator AG1 (1-5 μΜ; pre-incubated overnight) reduces the extent of hemolysis with 5 μΜ in human erythrocytes suspension (5%) exposed to either 1 mM chloroquine (CQ; 4 hours) or diamide (a GSH oxidant; 4 hours). G6PD activator AG1 increases GSH levels and reduced ROS levels together with increased G6PD activity under these drug-induced oxidative stress. [1] G6PD activator AG1 (50, 100, 250, 500, 750, 1000 nM) increases the viability by 20% and the proteolytic stability of Canton G6PD in SH-SY5Y cells. G6PD activator AG1 has no effect when G6PD was knocked down by siRNA, supporting the specificity of G6PD activator AG1 toward G6PD. [1]

Chemical Properties

Molecular Weight	438.65
Formula	C₂₄H₃₀N₄S₂
Cas No.	421581-52-4
Smiles	S(SCCNCCC1=CNC=2C=CC=CC21)CCNCCC3=CNC=4C=CC=CC43
Relative Density.	1.244 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature,The compound is unstable in solution. Please use soon | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (341.96 mM), Sonication is recommended. (The compound is unstable in solution, please use soon.)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.56 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2797 mL	11.3986 mL	22.7972 mL	113.9861 mL
5 mM	0.4559 mL	2.2797 mL	4.5594 mL	22.7972 mL
10 mM	0.2280 mL	1.1399 mL	2.2797 mL	11.3986 mL
20 mM	0.1140 mL	0.5699 mL	1.1399 mL	5.6993 mL
50 mM	0.0456 mL	0.2280 mL	0.4559 mL	2.2797 mL
100 mM	0.0228 mL	0.1140 mL	0.2280 mL	1.1399 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc