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Chrysotoxine (Synonyms: Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-, 4-[2-(3,4-Dimethoxyphenyl)ethy...)

Name: Chrysotoxine
Brand: TargetMol
SKU: T27012
Price: 133 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T27012 Copy Product Info

Purity: 99.34%

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Chrysotoxine (Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-) inhibits 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via NF-κB modulation and mitochondria protection.

Chrysotoxine

Copy Product Info

😃Good

Catalog No. T27012

Synonyms Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-, 4-[2-(3,4-Dimethoxyphenyl)ethyl]-2,6-dimethoxyphenol

Chrysotoxine (Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-) inhibits 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via NF-κB modulation and mitochondria protection.

Cas No. 156951-82-5

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Pack Size	Price	USA Stock	Global Stock
1 mg	$133	In Stock	In Stock
5 mg	$298	In Stock	In Stock
10 mg	$453	In Stock	In Stock
25 mg	$747	In Stock	In Stock
50 mg	$1,050	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$297	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.34%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Chrysotoxine AI Summary

Chrysotoxine exhibits multiple bioactivities. It shows significant antioxidant activity with an IC50 value of 14000.0 nM in the DPPH radical scavenging assay. Additionally, it has demonstrated anti-cancer properties against human NCI-H23 cells (IC50 value of 145470.0 nM) and cytotoxicity against human NCI-H460 cells (IC50 value of 127340.0 nM). The compound also provides neuroprotective effects against Amyloid beta (25 to 35)-induced toxicity in rat PC-12 cells, where it increases cell viability at concentrations of 50 μM, 25 μM, and 10 μM, with activity percentages ranging from 52.72% to 58.89%. Furthermore, its permeability is evaluated by the PAMPA-BBB assay, with a measured rate of 4.1 x 10^-6 cm/s..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Chrysotoxine (Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-) inhibits 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via NF-κB modulation and mitochondria protection.
Synonyms	Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-, 4-[2-(3,4-Dimethoxyphenyl)ethyl]-2,6-dimethoxyphenol

Chemical Properties

Molecular Weight	318.36
Formula	C₁₈H₂₂O₅
Cas No.	156951-82-5
Smiles	C(CC1=CC(OC)=C(OC)C=C1)C2=CC(OC)=C(O)C(OC)=C2
Relative Density.	1.147 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (172.76 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1411 mL	15.7055 mL	31.4110 mL	157.0549 mL
5 mM	0.6282 mL	3.1411 mL	6.2822 mL	31.4110 mL
10 mM	0.3141 mL	1.5705 mL	3.1411 mL	15.7055 mL
20 mM	0.1571 mL	0.7853 mL	1.5705 mL	7.8527 mL
50 mM	0.0628 mL	0.3141 mL	0.6282 mL	3.1411 mL
100 mM	0.0314 mL	0.1571 mL	0.3141 mL	1.5705 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc