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Tubulin inhibitor 24
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Catalog No. T9812Cas No. 2415761-65-6
Tubulin inhibitor 24 is a potent compound that inhibits tubulin polymerization.
Tubulin inhibitor 24
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Purity: 99.99%
Catalog No. T9812Cas No. 2415761-65-6
Tubulin inhibitor 24 is a potent compound that inhibits tubulin polymerization.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $117 | In Stock | In Stock | |
| 5 mg | $262 | In Stock | In Stock | |
| 10 mg | $387 | In Stock | In Stock | |
| 25 mg | $592 | In Stock | In Stock | |
| 50 mg | $828 | In Stock | In Stock | |
| 100 mg | $1,110 | - | In Stock | |
| 500 mg | $2,230 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.99%
Appearance:Solid
Color:Yellow
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Product Introduction
Tubulin inhibitor 24 AI Summary
Tubulin inhibitor 24 exhibits potent antiproliferative activity against various human cancer cell lines, including HeLa, MCF7, A549, and HCT-116, as well as mouse B16-F0 cells, with IC50 values ranging from 3.0 nM to 48.0 nM. It inhibits pig brain tubulin polymerization with an IC50 of 2100.0 nM and demonstrates binding affinity to pig brain tubulin under various temperatures and preincubation conditions. Additionally, the compound shows good metabolic stability in human and mouse liver microsomes, with half-lives of approximately 2 hours. In terms of antitumour activity, Tubulin inhibitor 24 significantly reduces tumour weight and volume in mice transplanted with B16-F0 cells, with activity percentages ranging from 38.6% to 77.4% at different doses..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Tubulin inhibitor 24 is a potent compound that inhibits tubulin polymerization. |
| Molecular Weight | 375.42 |
| Formula | C22H21N3O3 |
| Cas No. | 2415761-65-6 |
| Smiles | O(C)C=1C=C(C=2N3C(=CC(=N3)C4=CC=C(C)C=C4)N=CC2)C=C(OC)C1OC |
| Relative Density. | 1.21 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 11 mg/mL (29.3 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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