FK-448 Free base

Name: FK-448 Free base
Brand: TargetMol
SKU: T11290
Rating: 4.5 (1 reviews)

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Catalog No. T11290Cas No. 85858-76-0

FK-448 Free base is a potent and specific chymotrypsin inhibitor, with an IC50 of 720 nM.

FK-448 Free base

😃Good

Catalog No. T11290Cas No. 85858-76-0

FK-448 Free base is a potent and specific chymotrypsin inhibitor, with an IC50 of 720 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	6-8 weeks	6-8 weeks
50 mg	$1,980	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	FK-448 Free base is a potent and specific chymotrypsin inhibitor, with an IC50 of 720 nM.
Targets&IC50	Chymotrypsin:720 nM
In vitro	FK-448 Free base slightly inhibits esterolysis of Trypsin and Thrombin, with IC50s of 780 and 35 μM, respectively, but shows no effects on esterolysis of plasmin, plasma kallikrein or pancreas kallikrein, with IC50s of all >1 mM. FK-448 moderately inhibits hydrolytic activities of cathepsin G with an IC50 of 15 μM. FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC50 of 720 nM.
In vivo	FK-448, administered orally (p.o.) at a dose of 20 mg/kg, not only reduces the blood glucose level but also elevates the plasma Insulin Release Inhibitor (IRI) level in dogs. Meanwhile, when delivered intraperitoneally (i.p.) at the same dosage, FK-448 leads to a decreased blood glucose level and prevents the breakdown of insulin by pancreatic enzymes in rats.

Chemical Properties

Molecular Weight	406.52
Formula	C₂₅H₃₀N₂O₃
Cas No.	85858-76-0
Smiles	C(OC1=CC=C(C(=O)N2CCN(C(C)C)CC2)C=C1)(=O)C3C=4C(CCC3)=CC=CC4
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc