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Anti-Pentraxin 3 Antibody (8A587)
🥰Excellent
Catalog No. TMAY-02228
Anti-Pentraxin 3 Antibody (8A587) is a Mouse antibody targeting Pentraxin 3. Anti-Pentraxin 3 Antibody (8A587) can be used in ELISA.
Anti-Pentraxin 3 Antibody (8A587)
Anti-Pentraxin 3 Antibody (8A587)
🥰Excellent
Catalog No. TMAY-02228
Anti-Pentraxin 3 Antibody (8A587) is a Mouse antibody targeting Pentraxin 3. Anti-Pentraxin 3 Antibody (8A587) can be used in ELISA.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Pentraxin 3 Antibody (8A587) is a Mouse antibody targeting Pentraxin 3. Anti-Pentraxin 3 Antibody (8A587) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG2a |
| Clone | 8A587 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PTX3 / Pentraxin 3 / TSG-14 (rh PTX3 / Pentraxin 3 / TSG-14; TMPY-01816; NP_002843.2; Met 1-Ser 381). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor (TLR) engagement. PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. PTX3 interacts with several ligands, including growth factors, extracellular matrix components and selected pathogens, playing a role in complement activation and facilitating pathogen recognition by phagocytes, acting as a predecessor of antibodies. PTX3 may also contribute to the pathogenesis of atherosclerosis. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human PTX3 / Pentraxin 3 / TSG-14 protein (TMPY-01816) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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