Shopping Cart

Your shopping cart is currently empty

Indacaterol

Name: Indacaterol
Brand: TargetMol
SKU: T2320
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T2320Cas No. 312753-06-3

Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist.

Indacaterol

Copy Product Info

😃Good

Purity: 99.96%

Catalog No. T2320Cas No. 312753-06-3

Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$43	In Stock	In Stock
50 mg	$62	-	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.96%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Indacaterol AI Summary

Indacaterol exhibits significant agonist activity at the human beta2 adrenergic receptor, showing a high potency with an EC50 of 11.0 nM for increasing cAMP levels. It effectively inhibits bronchoconstriction in guinea pig tracheal strips, evidenced by an IC50 of 7.9 nM against electrically-induced conditions and an ED80 of 14.0 ug/kg against histamine-induced constriction. The compound also demonstrates a strong binding affinity for the beta2 adrenoceptor (Ki = 76.0 nM) and a moderate affinity for the beta1 adrenoceptor (IC50 = 316.23 nM), indicating a selective beta2 activity profile (selectivity ratio of 21.0). Pharmacokinetics data reveal a high plasma protein binding percentage (PPB = 95.1%), a terminal half-life of 7.6 hours in rats, and notable metabolism in rat liver microsomes. Additionally, Indacaterol shows efficacy in inhibiting serotonin and acetylcholine-induced bronchoconstriction as well as minor activity against SARS-CoV-2, human HDAC6 (15.57% inhibition), and human CYP1B1 inhibition (IC50 = 59200.0 nM). The compound also involves in GPCR beta-arrestin recruitment assays, exhibiting activation and inhibition across various receptors. However, it displays moderate lipophilicity with a log P value of 3.05 and shows cytotoxicity against human HepG2 cells with an IC50 of 9100.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist.
Targets&IC50	β1-adrenoceptor:7.36(pKi), β2-adrenoceptor:5.48(pKi)

Chemical Properties

Molecular Weight	392.49
Formula	C₂₄H₂₈N₂O₃
Cas No.	312753-06-3
Smiles	CCc1cc2CC(Cc2cc1CC)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12
Relative Density.	1.27 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 49.59 mg/mL (126.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.1 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5478 mL	12.7392 mL	25.4784 mL	127.3918 mL
5 mM	0.5096 mL	2.5478 mL	5.0957 mL	25.4784 mL
10 mM	0.2548 mL	1.2739 mL	2.5478 mL	12.7392 mL
20 mM	0.1274 mL	0.6370 mL	1.2739 mL	6.3696 mL
50 mM	0.0510 mL	0.2548 mL	0.5096 mL	2.5478 mL
100 mM	0.0255 mL	0.1274 mL	0.2548 mL	1.2739 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc