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Naspm trihydrochloride

Name: Naspm trihydrochloride
Brand: TargetMol
SKU: T12187L
Rating: 4.5 (1 reviews)

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Catalog No. T12187LCas No. 1049731-36-3

Alias 1-Naphthylacetyl spermine trihydrochloride

Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride) is a synthetic analogue of Joro spider toxin and acts as an antagonist of calcium-permeable AMPA (CP-AMPA) receptors.

Naspm trihydrochloride

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Catalog No. T12187LAlias 1-Naphthylacetyl spermine trihydrochlorideCas No. 1049731-36-3

Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride) is a synthetic analogue of Joro spider toxin and acts as an antagonist of calcium-permeable AMPA (CP-AMPA) receptors.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$54	6-8 weeks	6-8 weeks
5 mg	$87	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$92	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride) is a synthetic analogue of Joro spider toxin and acts as an antagonist of calcium-permeable AMPA (CP-AMPA) receptors.
Targets&IC50	AMPAR:0.33 μM
In vitro	NASPM selectively suppressed the inwardly rectifying and Ca(2+)-permeable AMPA receptors expressed in type II neurons. It had no effect on AMPA receptors in type I neurons. The blocking effect of NASPM on the Ca(2+)-permeable AMPA receptors was use and voltage-dependent. When the effect of NASPM reached a steady state, current responses induced by ionophoretic applications of kainate, a non-desensitizing agonist of AMPA receptors, in type II neurons were suppressed by NASPM in a dose-dependent manner at -60 mV (IC50 0.33 microM, and Hill coefficient 0.94). The response to kainate recovered partially after washing out NASPM. NASPM did not affect the Ca(2+)-permeable AMPA receptors when the neuronal membrane was held at potentials more positive than +40 mV. Furthermore, the blockade by NASPM which was attained at negative potentials was transiently removed by shifting membrane potential to +60 mV for 5 s together with a single ionophoretic application of kainate.
Synonyms	1-Naphthylacetyl spermine trihydrochloride

Chemical Properties

Molecular Weight	479.91
Formula	C₂₂H₃₇Cl₃N₄O
Cas No.	1049731-36-3
Smiles	[H]Cl.[H]Cl.[H]Cl.NCCCNCCCCNCCCNC(CC1=C2C=CC=CC2=CC=C1)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (104.19 mM), Sonication is recommended.

DMSO: 6.4 mg/mL (13.34 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.0837 mL	10.4186 mL	20.8372 mL	104.1862 mL
5 mM	0.4167 mL	2.0837 mL	4.1674 mL	20.8372 mL
10 mM	0.2084 mL	1.0419 mL	2.0837 mL	10.4186 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.1042 mL	0.5209 mL	1.0419 mL	5.2093 mL
50 mM	0.0417 mL	0.2084 mL	0.4167 mL	2.0837 mL
100 mM	0.0208 mL	0.1042 mL	0.2084 mL	1.0419 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc