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Picolinafen
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Catalog No. T211625Cas No. 137641-05-5
Alias AC 900001
Picolinafen is a pyridine herbicide that functions as an inhibitor of phytoene desaturase (PDS) and is utilized for its ability to manage the growth of broadleaf weeds by disrupting carotenoid biosynthesis. It exhibits cytotoxicity towards porcine trophoblast cells (pTr) and porcine luminal epithelial cells (pLE). By inducing the accumulation of reactive oxygen species (ROS), depleting calcium, and activating MAPK and PI3K signaling pathways, Picolinafen leads to reduced cell viability, increased apoptosis, impaired migration abilities, and altered expression of implantation-related genes, ultimately affecting the implantation capability of pTr cells. The LD50 value of Picolinafen for mammals is 2.7 mg/kg, and it is 7 μg/L for fish. Additionally, Picolinafen shows toxic effects during zebrafish embryonic development.
Picolinafen
😃Good
Catalog No. T211625Alias AC 900001Cas No. 137641-05-5
Picolinafen is a pyridine herbicide that functions as an inhibitor of phytoene desaturase (PDS) and is utilized for its ability to manage the growth of broadleaf weeds by disrupting carotenoid biosynthesis. It exhibits cytotoxicity towards porcine trophoblast cells (pTr) and porcine luminal epithelial cells (pLE). By inducing the accumulation of reactive oxygen species (ROS), depleting calcium, and activating MAPK and PI3K signaling pathways, Picolinafen leads to reduced cell viability, increased apoptosis, impaired migration abilities, and altered expression of implantation-related genes, ultimately affecting the implantation capability of pTr cells. The LD50 value of Picolinafen for mammals is 2.7 mg/kg, and it is 7 μg/L for fish. Additionally, Picolinafen shows toxic effects during zebrafish embryonic development.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Chemical Properties
Storage & Solubility Information
| Description | Picolinafen is a pyridine herbicide that functions as an inhibitor of phytoene desaturase (PDS) and is utilized for its ability to manage the growth of broadleaf weeds by disrupting carotenoid biosynthesis. It exhibits cytotoxicity towards porcine trophoblast cells (pTr) and porcine luminal epithelial cells (pLE). By inducing the accumulation of reactive oxygen species (ROS), depleting calcium, and activating MAPK and PI3K signaling pathways, Picolinafen leads to reduced cell viability, increased apoptosis, impaired migration abilities, and altered expression of implantation-related genes, ultimately affecting the implantation capability of pTr cells. The LD50 value of Picolinafen for mammals is 2.7 mg/kg, and it is 7 μg/L for fish. Additionally, Picolinafen shows toxic effects during zebrafish embryonic development. |
| In vitro | Picolinafen, at concentrations of 0.2-6 μM over 48 hours, reduces the viability of porcine trophectoderm cells (pTr) and uterine luminal epithelial cells (pLE), while altering their cell cycle. At 1-4 μM for the same duration, it induces apoptosis in these cells, disrupts their spheroid self-assembly ability, and impairs mitochondrial integrity and calcium homeostasis. Additionally, exposure to 1-4 μM for 2-48 hours leads to ROS accumulation and disturbance of intracellular Ca²⁺ regulation in pTr and pLE cells. At 4 μM over 15-24 hours, picolinafen inhibits migration of pTr cells and modifies transcriptional regulation of genes involved in apoptosis and implantation. Furthermore, within 3 hours at 1-4 μM, it activates the MAPK and PI3K/AKT signaling pathways in pTr and pLE cells. |
| In vivo | Picolinafen, when incubated at concentrations between 0.1-100 μM for 0-5 days, has an LC50 of 10 μM at 3 days and 5 μM at 5 days in zebrafish embryos. Additionally, Picolinafen, at concentrations of 1-10 μM and incubated for 24-72 hours, exhibits toxic effects during zebrafish embryo development. |
| Synonyms | AC 900001 |
| Molecular Weight | 376.30 |
| Formula | C19H12F4N2O2 |
| Cas No. | 137641-05-5 |
| Smiles | O=C(NC1=CC=C(F)C=C1)C2=NC(OC3=CC=CC(=C3)C(F)(F)F)=CC=C2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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