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Anti-Phospho-EGFR (Y1173) Antibody (4R680)

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Catalog No. TMAC-03206

Anti-Phospho-EGFR (Y1173) Antibody (4R680) is a Rabbit antibody targeting Phospho-EGFR (Y1173). Anti-Phospho-EGFR (Y1173) Antibody (4R680) can be used in WB,ICC,IHC,IP.

Anti-Phospho-EGFR (Y1173) Antibody (4R680)

Anti-Phospho-EGFR (Y1173) Antibody (4R680)

😃Good
Catalog No. TMAC-03206
Anti-Phospho-EGFR (Y1173) Antibody (4R680) is a Rabbit antibody targeting Phospho-EGFR (Y1173). Anti-Phospho-EGFR (Y1173) Antibody (4R680) can be used in WB,ICC,IHC,IP.
Pack SizePriceAvailabilityQuantity
50 μL$2987-10 days
100 μL$4967-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-EGFR (Y1173) Antibody (4R680) is a Rabbit antibody targeting Phospho-EGFR (Y1173). Anti-Phospho-EGFR (Y1173) Antibody (4R680) can be used in WB,ICC,IHC,IP.
Ig Type
IgG
Reactivity
Human
Application
Recommended Dose
WB: 1:1000; IHC: 1:50-200; ICC: 1:50-200
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionHybridoma Monoclonal Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundEpidermal growth factor mediates its effects on cell growth through its inter-action with a cell surface glycoprotein designated the EGF receptor. Binding of EGF or TGF alpha to the EGF receptor activates tyrosine-specific protein kinase activity intrinsic to the EGF receptor. The carboxy terminal tyrosine residues on EGFR, Tyr 1068 and Tyr 1173, are the major sites of autophosphorylation, which occurs as a result of EGF binding. Once activated, EGFR mediates the binding of the phosphotyrosine binding (PTB) domain of GRB2 through direct interactions with Tyr 1068 and Tyr 1086 and through indirect interactions with Tyr 1173 in the Ras signaling pathway. Tyr 1173 of EGFR also functions as a kinase substrate. Phosphorylation of Tyr 992, Tyr 1068 and Tyr 1086 is required for conformational change in the C-terminal tail of the EGF receptor.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
A synthesized phosphopeptide: human EGFR around the phosphorylation site of Tyr1173
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 175 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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