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Isovaleramide

Name: Isovaleramide
Brand: TargetMol
SKU: T0361
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0361Cas No. 541-46-8

Alias 3-Methylbutanamide

Isovaleramide (3-Methylbutanamide) is an anticonvulsant molecule isolated from Valeriana pavonii, which can inhibit the liver alcohol dehydrogenases.

Isovaleramide

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Purity: 98.93%

Catalog No. T0361Alias 3-MethylbutanamideCas No. 541-46-8

Isovaleramide (3-Methylbutanamide) is an anticonvulsant molecule isolated from Valeriana pavonii, which can inhibit the liver alcohol dehydrogenases.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$34	In Stock	In Stock
500 mg	$55	In Stock	In Stock
1 g	$80	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.93%

Appearance:Solid

Color:White

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COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	Isovaleramide (3-Methylbutanamide) is an anticonvulsant molecule isolated from Valeriana pavonii, which can inhibit the liver alcohol dehydrogenases.
In vitro	Research on the reproductive toxicity of Isovaleramide in mice, rats, and rabbits demonstrates its potential to be significantly lower than that of VPA. Oral administration of Isovaleramide at a dose of 100 mg/kg resulted in a 90% protection index against maximal electroshock seizures in mice.
In vivo	At a concentration of 0.15%, Isovaleramide induces the formation of nitrile hydratase in Rhodococcus sp. YH 3-3. In in vitro assays, 300 μM Isovaleramide inhibits 42% of 3H-FNZ binding to its target site. At concentrations up to 1000 μM, Isovaleramide does not affect the binding and uptake assays of various neurotransmitters in vitro, suggesting that its mechanism of action does not involve direct receptor-mediated effects.
Synonyms	3-Methylbutanamide

Chemical Properties

Molecular Weight	101.15
Formula	C₅H₁₁NO
Cas No.	541-46-8
Smiles	CC(C)CC(N)=O
Relative Density.	0.901g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 16 mg/mL (158.18 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 75 mg/mL (741.47 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (19.77 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	9.8863 mL	49.4315 mL	98.8631 mL	494.3154 mL
5 mM	1.9773 mL	9.8863 mL	19.7726 mL	98.8631 mL
10 mM	0.9886 mL	4.9432 mL	9.8863 mL	49.4315 mL
20 mM	0.4943 mL	2.4716 mL	4.9432 mL	24.7158 mL
50 mM	0.1977 mL	0.9886 mL	1.9773 mL	9.8863 mL
100 mM	0.0989 mL	0.4943 mL	0.9886 mL	4.9432 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc