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SAX-187

Name: SAX-187
Brand: TargetMol
SKU: T3183
Price: 76 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3183Cas No. 554403-49-5

Alias WAY181187, WAY 181187

SAX-187 (SAX-187) has high-affinity binding at the human 5-HT6 receptor.

SAX-187

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Purity: 98%

Catalog No. T3183Alias WAY181187, WAY 181187Cas No. 554403-49-5

SAX-187 (SAX-187) has high-affinity binding at the human 5-HT6 receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$76	In Stock	In Stock
5 mg	$163	In Stock	In Stock
10 mg	$273	In Stock	In Stock
25 mg	$442	In Stock	In Stock
50 mg	$592	In Stock	In Stock
100 mg	$816	In Stock	In Stock
200 mg	$1,080	-	In Stock
1 mL x 10 mM (in DMSO)	$178	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98%

Appearance:solid

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COA

Product Introduction

SAX-187 AI Summary

SAX-187 exhibits high affinity for the human 5HT6 receptor, with a Ki of 2.0 nM, and acts as an agonist with an EC50 of 6.5 nM and an Emax of 95.5%. It also inhibits the human 5HT2B and 5HT2C receptors with Ki values of 458.0 nM and 124.0 nM, respectively. The compound demonstrates good solubility at pH 3 to 6 (> 10000.0 µg/mL) but lower solubility at pH 8 (240.0 µg/mL), and moderate permeability (13.6 x 10^6 cm/s) in an artificial membrane. It shows varied metabolic stability across different species' liver microsomes and has a long half-life in human liver microsomes (> 1 hour). Pharmacokinetically, SAX-187 has good oral bioavailability in rats (23%) and dogs (55%), with good brain penetration indicated by the brain-to-plasma level ratio..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	SAX-187 (SAX-187) has high-affinity binding at the human 5-HT6 receptor.
Targets&IC50	5-HT6 receptor:6.6 nM (EC50), 5-HT6 receptor:2.2 nM (Ki)
Synonyms	WAY181187, WAY 181187

Chemical Properties

Molecular Weight	380.87
Formula	C₁₅H₁₃ClN₄O₂S₂
Cas No.	554403-49-5
Smiles	NCCc1cn(c2ccccc12)S(=O)(=O)c1c(Cl)nc2sccn12
Relative Density.	1.67 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (157.53 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.25 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6256 mL	13.1278 mL	26.2557 mL	131.2784 mL
5 mM	0.5251 mL	2.6256 mL	5.2511 mL	26.2557 mL
10 mM	0.2626 mL	1.3128 mL	2.6256 mL	13.1278 mL
20 mM	0.1313 mL	0.6564 mL	1.3128 mL	6.5639 mL
50 mM	0.0525 mL	0.2626 mL	0.5251 mL	2.6256 mL
100 mM	0.0263 mL	0.1313 mL	0.2626 mL	1.3128 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc