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SKF38393 hydrobromide

Name: SKF38393 hydrobromide
Brand: TargetMol
SKU: T23359
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23359Cas No. 20012-10-6

Alias SKF 38393 hydrobromide

SKF38393 hydrobromide is the salt form of SKF38393.SKF38393 is a dopamine D1 receptor agonist that increases the expression of Shati/Nat8L mRNA in the NAc of mice; increases the frequency of 5-hydroxytryptamine and n -methyl- D -aspartate-induced locomotion-associated ruptures in astrocytes; can mimic the dopamine-induced inhibition of colonic motility in mice; can promote locust swarming

SKF38393 hydrobromide

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Purity: 98.99%

Catalog No. T23359Alias SKF 38393 hydrobromideCas No. 20012-10-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	-	In Stock
5 mg	$89	-	In Stock
10 mg	$128	-	In Stock
25 mg	$259	-	In Stock
50 mg	$383	-	In Stock
100 mg	$569	-	In Stock
200 mg	$816	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98.99%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	SKF38393 hydrobromide is the salt form of SKF38393.SKF38393 is a dopamine D1 receptor agonist that increases the expression of Shati/Nat8L mRNA in the NAc of mice; increases the frequency of 5-hydroxytryptamine and n -methyl- D -aspartate-induced locomotion-associated ruptures in astrocytes; can mimic the dopamine-induced inhibition of colonic motility in mice; can promote locust swarming
Targets&IC50	D1 receptor:110 nM
In vitro	Methods: To assess the role of dopamine receptor subtypes in the initiation of behavioral sensitization to cocaine, the partial D1 agonist SKF-38393 (0.01-1.0 μg/side), the D2/3 agonist quinpirole (0.1-1.0 μg/side), or saline was infused once daily into the ventral tegmental area (VTA) or nucleus accumbens shell over 3 days. Results: 1.0 μg/side SKF-38393 infusion into the nucleus accumbens shell produced significant behavioral hyperactivity after both the first and last daily infusions, with no significant differences in behavioral responses between days; repeated administration of SKF-38393 into the VTA resulted in sensitization to the locomotor activating effects of cocaine.[6]
In vivo	Methods: To assess the role of dopamine receptor subtypes in the initiation of behavioral sensitization to cocaine, the partial D1 agonist SKF38393 hydrobromide (0.01-1.0 μg/side), the D2/3 agonist quinpirole (0.1-1.0 μg/side), or saline was infused once daily into the ventral tegmental area (VTA) or nucleus accumbens shell over 3 days. Results: 1.0 μg/side SKF38393 hydrobromide infusion into the nucleus accumbens shell produced significant behavioral hyperactivity after both the first and last daily infusions, with no significant differences in behavioral responses between days; repeated administration of SKF38393 hydrobromide into the VTA resulted in sensitization to the locomotor activating effects of cocaine.[1]
Synonyms	SKF 38393 hydrobromide

Chemical Properties

Molecular Weight	336.22
Formula	C₁₆H₁₈BrNO₂
Cas No.	20012-10-6
Smiles	Br.OC=1C=C2C(=CC1O)C(C=3C=CC=CC3)CNCC2
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 10 mg/mL (29.74 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.9742 mL	14.8712 mL	29.7424 mL	148.7122 mL
5 mM	0.5948 mL	2.9742 mL	5.9485 mL	29.7424 mL
10 mM	0.2974 mL	1.4871 mL	2.9742 mL	14.8712 mL
20 mM	0.1487 mL	0.7436 mL	1.4871 mL	7.4356 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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