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RXFP receptor

RXFP1, or the relaxin family peptide receptor 1, functions as the receptor for relaxin-2, exerting a pivotal influence on the regulation of reproductive and cardiovascular physiology. Recognized as a prominent therapeutic target, RXFP1 holds significance for its substantial impact on various physiological processes. Structurally, RXFP1 is identified as a multi-domain G protein-coupled receptor (GPCR) characterized by an ectodomain that includes an LDLa module and leucine-rich repeats. This intricate structural arrangement underscores the crucial role of RXFP1 in mediating the biological effects of relaxin-2, positioning it as a key player in both physiological and therapeutic contexts.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T16101 ML-290 1482500-76-4 98%
ML-290
ML-290 is an effective relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes. It shows an EC50 of 94 nM.
T62929 RLX-33 2784577-71-3 99.82%
RLX-33
RLX-33 is a potent and selective antagonist of relaxin family peptide 3 (RXFP3) that crosses the blood-brain barrier and also blocks relaxin 3-induced ERK1/2 pho...
T63838 AZD5462 2787501-83-9 99.63%
AZD5462
AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.
T61964 RXFP3/4 agonist 2 2752378-78-0 98%
RXFP3/4 agonist 2
RXFP3/4 agonist 2 is a potent non-peptidic bis-RXFP3/4 agonist that induces the interaction between RXFP3 and β-arrestin-2, and can be used to study diseases cau...
ML-290
T16101
ML-290 is an effective relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes. It shows an EC50 of 94 nM.
RLX-33
T62929
RLX-33 is a potent and selective antagonist of relaxin family peptide 3 (RXFP3) that crosses the blood-brain barrier and also blocks relaxin 3-induced ERK1/2 pho...
AZD5462
T63838
AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.
RXFP3/4 agonist 2
T61964
RXFP3/4 agonist 2 is a potent non-peptidic bis-RXFP3/4 agonist that induces the interaction between RXFP3 and β-arrestin-2, and can be used to study diseases cau...
TargetMol