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Anti-Proteasome 20S alpha 1 Polyclonal Antibody

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Catalog No. TMAB-11800

Anti-Proteasome 20S alpha 1 Polyclonal Antibody is a Rabbit antibody targeting Proteasome 20S alpha 1. Anti-Proteasome 20S alpha 1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.

Anti-Proteasome 20S alpha 1 Polyclonal Antibody

Anti-Proteasome 20S alpha 1 Polyclonal Antibody

😃Good
Catalog No. TMAB-11800
Anti-Proteasome 20S alpha 1 Polyclonal Antibody is a Rabbit antibody targeting Proteasome 20S alpha 1. Anti-Proteasome 20S alpha 1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2227-10 days7-10 days
100 μL$3747-10 days7-10 days
200 μL$5277-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-Proteasome 20S alpha 1 Polyclonal Antibody is a Rabbit antibody targeting Proteasome 20S alpha 1. Anti-Proteasome 20S alpha 1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm. Nucleus.
Tissue SpecificityInduced in breast cancer tissue (at protein level). Up-regulated in liver tumor tissues.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundUbiquitin-dependent proteolysis mediates selective destruction of various cell cycle regulators, transcription factors and tumor suppressors. In eukaryotic cells, selective breakdown of cellular proteins is ensured by their ubiquitination and subsequent degradation by the 26S proteasome. At specific stages of development, embryo- and tissue-specific components of the 26S proteasome form, facilitating proteolysis. 20S Proteasome ?, also designated macropain subunit C2 or PROS-30, is a prosomal protein involved in a non-lysosomal ATP/ubiquitin-dependent proteolytic pathway. The entire proteasome is composed of at least 15 non-identical subunits which form a highly-ordered ring-shaped structure.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human Proteasome 20S alpha
Antigen Species
Human
Gene Name
PSMA1
Gene ID
Protein Name
Proteasome subunit alpha type-1
Uniprot ID
Function
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal transduction in the macrophage proteasome (By similarity). Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells.
Chemical Properties
Molecular WeightTheoretical: 30 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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