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Atogepant

Name: Atogepant
Brand: TargetMol
SKU: T26682
Price: 158 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26682Cas No. 1374248-81-3

Alias MK8031. Atogepant, MK-8031, MK 8031, AGN-241689, AGN241689

Atogepant (MK-8031) is an orally available, selective and potent calcitonin gene-related peptide receptor (CGRP) antagonist for the study of migraine.

Atogepant

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Purity: 99.66%

Catalog No. T26682Alias MK8031. Atogepant, MK-8031, MK 8031, AGN-241689, AGN241689Cas No. 1374248-81-3

Atogepant (MK-8031) is an orally available, selective and potent calcitonin gene-related peptide receptor (CGRP) antagonist for the study of migraine.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$158	In Stock	In Stock
5 mg	$278	In Stock	In Stock
10 mg	$347	In Stock	In Stock
25 mg	$689	In Stock	In Stock
50 mg	$1,230	-	In Stock
100 mg	$1,790	-	In Stock
200 mg	$2,420	-	In Stock
1 mL x 10 mM (in DMSO)	$372	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.66%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Atogepant (MK-8031) is an orally available, selective and potent calcitonin gene-related peptide receptor (CGRP) antagonist for the study of migraine.
Targets&IC50	CGRP receptors (mouse):0.13 nM (Ki), CGRP receptors (rat):0.7 nM (Ki), CGRP receptors (rhesus macaque):0.009 nM (Ki), CGRP receptors (rabbit):2.1 nM (Ki), CGRP (human cloned):0.026 nM, CGRP receptors (human natural):0.026 nM (Ki), CGRP receptors (dog):1.2 nM (Ki), CGRP receptors (human cloned):0.015 nM (Ki)
In vitro	Atogepant has a CGRP IC50=0.026 nM for human clones. The binding affinities of Atogepant for human and non-human CGRP receptors were: human (cloned) Ki=0.015 nM, human (natural) Ki=0.026 nM, rhesus macaque Ki=0.009 nM, rat Ki=0.7 nM, mouse Ki=0.13 nM, rabbit Ki=2.1 nM, dog Ki=1.2 nM, respectively. [1][2]
In vivo	Oral administration of Atogepant to rats (at doses of 3, 10, and 30 mg/kg, respectively) once daily for 9 days showed that Atogepant effectively attenuated the abnormal facial pain induced by nitroglycerin and ameliorated the capsaicin-induced vasodilation of primate dermis in rats.[2]
Synonyms	MK8031. Atogepant, MK-8031, MK 8031, AGN-241689, AGN241689

Chemical Properties

Molecular Weight	603.52
Formula	C₂₉H₂₃F₆N₅O₃
Cas No.	1374248-81-3
Smiles	O=C1[C@@]2(C=3C(N1)=NC=CC3)CC=4C(C2)=NC=C(C(N[C@H]5C[C@H]([C@@H](C)N(CC(F)(F)F)C5=O)C6=C(F)C(F)=CC=C6F)=O)C4
Relative Density.	1.54 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (132.56 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6569 mL	8.2847 mL	16.5695 mL	82.8473 mL
5 mM	0.3314 mL	1.6569 mL	3.3139 mL	16.5695 mL
10 mM	0.1657 mL	0.8285 mL	1.6569 mL	8.2847 mL
20 mM	0.0828 mL	0.4142 mL	0.8285 mL	4.1424 mL
50 mM	0.0331 mL	0.1657 mL	0.3314 mL	1.6569 mL
100 mM	0.0166 mL	0.0828 mL	0.1657 mL	0.8285 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc