KB-5246

Name: KB-5246
Brand: TargetMol
SKU: T11744
Rating: 4.5 (1 reviews)

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Catalog No. T11744Cas No. 119474-55-4

KB-5246, displays antibacterial activities.is a tetracyclic quinolone.

KB-5246

😃Good

Catalog No. T11744Cas No. 119474-55-4

KB-5246, displays antibacterial activities.is a tetracyclic quinolone.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,670	6-8 weeks	6-8 weeks
50 mg	$2,180	6-8 weeks	6-8 weeks
100 mg	$2,800	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	KB-5246, displays antibacterial activities.is a tetracyclic quinolone.
In vitro	KB5246, a tetracyclic quinolone with antibacterial properties, effectively inhibits 90% of Escherichia coli, Klebsiella pneumoniae, and Klebsiella oxytoca isolates at concentrations of 0.10 μg/mL or lower. Notably, concentrations of KB-5246 at or above the minimum inhibitory concentration (MIC) prevent regrowth of these organisms after 24 hours of incubation. Additionally, the MICs for 90% of tested isolates (MIC90s) against key gram-positive microorganisms, including methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, and Streptococcus pyogenes, are 0.39 μg/mL, showcasing KB-5246's broad-spectrum antibacterial efficacy.
In vivo	The 50% effective dose (ED50) of KB-5246 for treating S. pneumoniae 2132 infections is 50.5 mg/kg. Its efficacy against S. aureus Smith, P. aeruginosa GN11189, and Serratia marcescens GN7577 is on par with ofloxacin and surpasses that of norfloxacin.

Chemical Properties

Molecular Weight	425.86
Formula	C₁₈H₁₇ClFN₃O₄S
Cas No.	119474-55-4
Smiles	Cl.O=C(O)C=1C(=O)C2=CC(F)=C(C=3OCC4=CSC1N4C32)N5CCN(C)CC5
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc