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Syk

Tyrosine-protein kinase SYK, also known as spleen tyrosine kinase, is an enzyme which in humans is encoded by the SYK gene.

  • GSK1904529A
    T60031089283-49-7In house
    GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .
    • $34
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    TargetMol | Citations Cited
  • Linocinnamarin
    TN7075554-87-0
    Linocinnamarin (3-[4-(beta-D-Glucopyranosyloxy)phenyl]acrylic acid methyl ester) is isolated from Fragaria ananassa Duch. (strawberry). The inhibition of antigen-stimulated degranulation by LN is mainly due to inactivation of Syk/phospholipase Cgamma (PLCgamma) pathways.
    • $148
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  • Syk-IN-3
    T130451312534-69-2In house
    Syk-IN-3 is a Syk inhibitor with potential anti-inflammatory and anticancer activity and can be used to study immune dysregulation.
    • $397
    In Stock
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  • BAY 61-3606
    T4263732983-37-8
    BAY 61-3606 (Syk inhibitor IV) is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.
    • $51
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  • RO9021
    T167761446790-62-0In house
    RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor (average IC50: 5.6 nM).
    • $79
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  • Ellagic acid
    T0465476-66-4
    Ellagic acid (Gallogen) is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clotting system which also causes kinin release; used in research and as a dye.
    • $44
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    TargetMol | Citations Cited
  • ANTHRAQUINONE-2-CARBOXYLIC ACID
    T7035117-78-2
    Anthraquinone-2-carboxylic acid acts as a potent anti-inflammatory and antinociceptive component in vivo, thus contributing to the immune regulatory role of fruits and herbs.
    • $40
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    TargetMol | Citations Cited
  • R406
    T6174841290-81-1
    R406 (R-406 besylate) is an effective Syk inhibitor (IC50: 41 nM) and shows no effects on Lyn.
    • $40
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    TargetMol | Citations Cited
  • Piceatannol
    T061010083-24-6
    Piceatannol (Astringenin) is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is synthetic from the conversion of resveratrol by cytochrome P450 1B1.
    • $39
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    TargetMol | Citations Cited
  • Entospletinib
    T61011229208-44-9
    Entospletinib (GS-9973) (IC50= 7.7 nM)is a specific Syk inhibitor, which is orally bioavailable.
    • $32
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    TargetMol | Citations Cited
  • Cevidoplenib dimesylate hydrochloride
    T9789269062-93-3
    Cevidoplenib dimesylate hydrochloride is a spleen tyrosine kinase (Syk) inhibitor showing potential immunomodulating and anti-inflammatory properties.
    • $122
    In Stock
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    TargetMol | Inhibitor Sale
  • Damnacanthal
    TN1549477-84-9
    Damnacanthal possesses anti-cancer, immunomodulatory, antinociceptive and anti-inflammatory actions, it can treat or prevent hepatocellular carcinoma through its inhibitory effects on the HGF/c-Met axis.
    • $814
    Backorder
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    TargetMol | Inhibitor Sale
  • OXSI-2
    T28281622387-85-3
    OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM. OXSI-2 completely inhibits Adaptor protein LAT Y191 phosphorylation and Syk mediated events in platelets.
    • $78
    35 days
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    TargetMol | Inhibitor Sale
  • R406 free base
    T2467841290-80-0
    R406 free base (R406 (free base)) is a potent Syk inhibitor.
    • $39
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  • Syk Inhibitor II dihydrochloride
    T4391227449-73-2
    Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibit
    • $132
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  • MNS
    T65941485-00-3
    MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.
    • $45
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  • PRT-060318
    T69571194961-19-7
    PRT-060318 (P142-76) is a novel selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.
    • $35
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  • Syk-IN-8
    T794432568963-01-7
    Syk-IN-8 (compound 19q) functions as a Syk inhibitor with demonstrated antiproliferative effects on a variety of hematological tumor cells. It specifically inhibits PLCγ2 phosphorylation and is applicable for blood cancer research [1].
    • Inquiry Price
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  • Fostamatinib Disodium
    T26051025687-58-4
    Fostamatinib Disodium (R788 Disodium) is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities.
    • $39
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  • R112
    T3185575474-82-7
    R112 is an ATP-competitive inhibitor of Syk kinase. Ki=6 nM,IC50=226 nM.
    • $33
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  • Cerdulatinib
    T24871198300-79-6
    Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.
    • $37
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  • PRT062607 hydrochloride
    T26961370261-97-4
    PRT062607 hydrochloride (P505-15 Hydrochloride) is a selective inhibitor of Syk (IC50: 1 nM). It displays at least 80-fold selectivity for Syk over other kinases.
    • $55
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  • Fostamatinib
    T6115901119-35-5
    Fostamatinib (R788)(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.
    • $36
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  • TAS05567
    T169951429038-15-2
    TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM). TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, JAK2, KDR, and RET with IC50s of 10 nM, 4.8 nM, 600 nM, and 29 nM, respectively) in a panel of 192 kinases.
    • $2,270
    Backorder
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  • Cerdulatinib hydrochloride
    T61041369761-01-2
    Cerdulatinib hydrochloride (PRT2070 hydrochloride) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19 other tested kinases with IC50 less than 200 nM.
    • $37
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  • SRX3207
    T224302254693-15-5
    SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.
    • $85
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  • TAK-659 hydrochloride
    T42091952251-28-3
    TAK-659 hydrochloride (TAK-659) is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent toward both SYK and FLT3.
    • $33
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  • Lanraplenib succinate
    T118241800047-00-0
    Lanraplenib succinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. Lanraplenib succinate is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases.
    • $59
    5 days
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  • ER-27319
    T78641201010-95-9
    ER-27319, an acridone derivative, serves as a potent and selective inhibitor of spleen tyrosine kinase (SYK), effectively impeding both the tyrosine phosphorylation and enzymatic activity of SYK. With an inhibitory concentration (IC50) of 10 µM, this compound suppresses the release of allergic mediators from human and rat mast cells triggered by antigens, making it useful for allergy research [1] [2].
    • $1,520
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  • Syk-IN-7
    T78943
    Syk-IN-7 (compound 17) acts as an inhibitor of spleen tyrosine kinase (SYK) [1].
    • Inquiry Price
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  • Syk Inhibitor II
    T4348726695-51-8
    Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).
    • $40
    5 days
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  • URMC-099
    T60571229582-33-5
    URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
    • $52
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  • Lanraplenib monosuccinate
    T11824L1800046-97-2
    Lanraplenib monosuccinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. Lanraplenib monosuccinate is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases.
    • $1,520
    Backorder
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  • Cevidoplenib dimesylate
    T394372043659-93-2
    Cevidoplenib dimesylate is an inhibitor of spleen tyrosine kinase (Syk), possessing anti-inflammatory and immunomodulating properties.
    • $98
    In Stock
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    TargetMol | Inhibitor Sale
  • Gusacitinib
    T143311425381-60-7
    Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).
    • $40
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  • Sovleplenib
    T320881415792-84-5
    Sovleplenib (HMPL523) is an orally available, selective and potent inhibitor of the splenic tyrosine kinase SYK with an IC50 of 25 nM.Sovleplenib has antitumor activity and may be used in studies of immune thrombocytopenia (ITP).
    • $222
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  • BAY 61-3606 dihydrochloride
    T6776648903-57-5
    BAY 61-3606 dihydrochloride (BAY 61-3606) is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM).
    • $53
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  • Lanraplenib
    T11824LL1800046-95-0
    Lanraplenib (GS-9876) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.
    • $47
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