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Angiogenesis Filter
Angiogenesis Tyrosine Kinase/AdaptorsACK1
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Syk
Spleen tyrosine kinase (SYK) is an important non-receptor tyrosine kinase involved in regulating signaling pathways of various cellular processes. It is mainly expressed in hematopoietic cells and bone marrow cells and is essential for B cell development, maturation and antibody production, and is a key therapeutic target for autoimmune and allergic diseases.
Gusacitinib
T143311425381-60-7
Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).
- $35
Size
QTY
Fostamatinib
T6115901119-35-5
Fostamatinib (R788)(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.
- $36
Size
QTY
Entospletinib
T61011229208-44-9
Entospletinib (GS-9973) is a Syk inhibitor (IC50=7.7 nM) with selective, oral activity. Entospletinib has potential value in the treatment of a variety of hematological malignancies and immune-related diseases.
- $32
Size
QTY
Fostamatinib Disodium
T26051025687-58-4
Fostamatinib Disodium (R788 Disodium) is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulatory activities.
- $39
Size
QTY
Syk-IN-3
T130451312534-69-2In house
Syk-IN-3 is a Syk inhibitor with potential anti-inflammatory and anticancer activity and can be used to study immune dysregulation.
- $397
Size
QTY
Piceatannol
T061010083-24-6
Piceatannol (Astringenin) is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is synthetic from the conversion of resveratrol by cytochrome P450 1B1.
- $39
Size
QTY
R406
T6174841290-81-1
R406 (R-406 besylate) is an effective Syk inhibitor (IC50: 41 nM) and shows no effects on Lyn.
- $40
Size
QTY
GSK1904529A
T60031089283-49-7In house
GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .
- $34
Size
QTY
URMC-099
T60571229582-33-5
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19 42 14 150 nM, for MLK1 MLK2 MLK3 DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
- $52
Size
QTY
Ellagic acid
T0465476-66-4
Ellagic acid (Gallogen), a thickened tetracyclic natural product, is a potent CK2 inhibitor (IC50=40 nM; Ki=20 nM) with ATP-competitive properties. Ellagic acid is an antioxidant and also possesses antiproliferative activity.
- $44
Size
QTY
R406 free base
T2467841290-80-0
R406 free base (R406 (free base)) is a potent Syk inhibitor.
- $39
Size
QTY
BAY 61-3606
T4263732983-37-8
BAY 61-3606 (Syk inhibitor IV) is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.
- $51
Size
QTY
Syk Inhibitor II dihydrochloride
T4391227449-73-2
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibit
- $132
Size
QTY
Cerdulatinib
T24871198300-79-6
Cerdulatinib (PRT2070) is an novel oral dual Syk JAK inhibitor.
- $37
Size
QTY
Cevidoplenib dimesylate
T394372043659-93-2
Cevidoplenib dimesylate is an inhibitor of spleen tyrosine kinase (Syk), possessing anti-inflammatory and immunomodulating properties.
- $59
Size
QTY
PRT-060318
T69571194961-19-7
PRT-060318 (P142-76) is a novel selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.
- $35
Size
QTY
Lanraplenib
T11824LL1800046-95-0
Lanraplenib (GS-9876) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) being developed for treating inflammatory diseases. It inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.
- $47
Size
QTY
Cerdulatinib hydrochloride
T61041369761-01-2
Cerdulatinib hydrochloride (PRT2070 hydrochloride) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM 6 nM 8 nM 0.5 nM and 32 nM for JAK1 JAK2 JAK3 TYK2 and Syk, respectively. Also inhibits 19 other tested kinases with IC50 less than 200 nM.
- $31
Size
QTY
Linocinnamarin
TN7075554-87-0
Linocinnamarin (3-[4-(beta-D-Glucopyranosyloxy)phenyl]acrylic acid methyl ester) is isolated from Fragaria ananassa Duch. (strawberry). The inhibition of antigen-stimulated degranulation by LN is mainly due to inactivation of Syk/phospholipase Cgamma (PLCgamma) pathways.
- $148
Size
QTY
SRX3207
T224302254693-15-5
SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.
- $51
Size
QTY
MNS
T65941485-00-3
MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.
- $43
Size
QTY
RO9021
T167761446790-62-0In house
RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor [average IC50: 5.6 nM].
- $40
Size
QTY
R112
T3185575474-82-7
R112 is an ATP-competitive inhibitor of Syk kinase. Ki=6 nM,IC50=226 nM.
- $33
Size
QTY
Sovleplenib
T320881415792-84-5
Sovleplenib (HMPL523) is an orally available, selective and potent inhibitor of the splenic tyrosine kinase SYK with an IC50 of 25 nM.Sovleplenib has antitumor activity and may be used in studies of immune thrombocytopenia (ITP).
- $129
Size
QTY
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