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lysosomal autophagy

Pre-lysosomes form de novo in the cytoplasm from a cup-shaped membrane called a phagophore. The edges of the phagophore expand while becoming spherical until they seal, enclosing the engulfed pieces of cytoplasm with whatever might lie inside, and giving rise to a double-membrane vesicle. Farquhar observed these closed vesicles, which are known as autophagosomes. Autophagosomes take up damaged molecules or organelles and carry this cargo to the lysosomes. When de Duve observed autophagosomes, he realized that cells could degrade their own components and named the process "autophagy"
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T3437 Lys05 1391426-24-6 98%
Lys05
Lys05, or Lys01 trihydrochloride, is a potent, water soluble lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more pote...
T1885 Siramesine hydrochloride 224177-60-0 98%
Siramesine hydrochloride
Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit ...
Lys05
T3437
Lys05, or Lys01 trihydrochloride, is a potent, water soluble lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more pote...
Siramesine hydrochloride
T1885
Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit ...
TargetMol