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Astin C

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Catalog No. TN3464Cas No. 148057-23-2
Alias Asterin

Astin C (Asterin), a naturally occurring cyclic peptide that can be extracted from Aster tataricus, specifically blocks IRF3 recruitment at the STING signalosome inhibiting cGAS-STING signaling and innate inflammatory responses triggered by cytoplasmic dna, resulting in mice that are more susceptible to HSV-1 infection and significantly attenuating autoinflammatory responses.

Astin C

Astin C

🥰Excellent
Catalog No. TN3464Alias AsterinCas No. 148057-23-2
Astin C (Asterin), a naturally occurring cyclic peptide that can be extracted from Aster tataricus, specifically blocks IRF3 recruitment at the STING signalosome inhibiting cGAS-STING signaling and innate inflammatory responses triggered by cytoplasmic dna, resulting in mice that are more susceptible to HSV-1 infection and significantly attenuating autoinflammatory responses.
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Product Introduction

Bioactivity
Description
Astin C (Asterin), a naturally occurring cyclic peptide that can be extracted from Aster tataricus, specifically blocks IRF3 recruitment at the STING signalosome inhibiting cGAS-STING signaling and innate inflammatory responses triggered by cytoplasmic dna, resulting in mice that are more susceptible to HSV-1 infection and significantly attenuating autoinflammatory responses.
Targets&IC50
Ifnb and Cxcl10 expression in IMR-90 cells via STING pathway:10.8  μM, Ifnb and Cxcl10 expression in MEFs via STING pathway:3.4  μM
In vitro
Astin C (10 μM, 6 h) inhibited the expression of DNA- or HSV-1–induced genes such as Ifnb and Cxcl10 in MEFs and IMR-90 cells, with IC₅₀ values of 3.4 μM and 10.8 μM respectively, indicating it is a STING pathway inhibitorp[1].
In vivo
In Trex1⁻/⁻ mice, Astin C (1 mg/kg, i.v., every other day for 14 days) reduced inflammatory gene expression across multiple tissues, alleviated autoimmune-related pathology, and decreased activated CD8⁺ T cells, showing anti-inflammatory and immunoregulatory effects[1].
AliasAsterin
Chemical Properties
Molecular Weight570.47
FormulaC25H33Cl2N5O6
Cas No.148057-23-2
SmilesO=C1NC(C(=O)N2CC(Cl)C(Cl)C2C(=O)NC(C(=O)NC(C(=O)NC(C=3C=CC=CC3)C1)CO)CC)CC
Relative Density.1.46g/cm3
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (140.24 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7529 mL8.7647 mL17.5294 mL87.6470 mL
5 mM0.3506 mL1.7529 mL3.5059 mL17.5294 mL
10 mM0.1753 mL0.8765 mL1.7529 mL8.7647 mL
20 mM0.0876 mL0.4382 mL0.8765 mL4.3824 mL
50 mM0.0351 mL0.1753 mL0.3506 mL1.7529 mL
100 mM0.0175 mL0.0876 mL0.1753 mL0.8765 mL

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