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Astin C

Name: Astin C
Brand: TargetMol
SKU: TN3464
Rating: 4.5 (1 reviews)

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Catalog No. TN3464Cas No. 148057-23-2

Alias Asterin

Astin C (Asterin), a naturally occurring cyclic peptide that can be extracted from Aster tataricus, specifically blocks IRF3 recruitment at the STING signalosome inhibiting cGAS-STING signaling and innate inflammatory responses triggered by cytoplasmic dna, resulting in mice that are more susceptible to HSV-1 infection and significantly attenuating autoinflammatory responses.

Astin C

🥰Excellent

Catalog No. TN3464Alias AsterinCas No. 148057-23-2

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Product Introduction

Bioactivity

Description	Astin C (Asterin), a naturally occurring cyclic peptide that can be extracted from Aster tataricus, specifically blocks IRF3 recruitment at the STING signalosome inhibiting cGAS-STING signaling and innate inflammatory responses triggered by cytoplasmic dna, resulting in mice that are more susceptible to HSV-1 infection and significantly attenuating autoinflammatory responses.
Targets&IC50	Ifnb and Cxcl10 expression (IMR-90 cells via STING pathway):10.8  μM, Ifnb and Cxcl10 expression (MEFs via STING pathway):3.4  μM
In vitro	Astin C (10 μM, 6 h) inhibited the expression of DNA- or HSV-1–induced genes such as Ifnb and Cxcl10 in MEFs and IMR-90 cells, with IC₅₀ values of 3.4 μM and 10.8 μM respectively, indicating it is a STING pathway inhibitorp[1].
In vivo	In Trex1⁻/⁻ mice, Astin C (1 mg/kg, i.v., every other day for 14 days) reduced inflammatory gene expression across multiple tissues, alleviated autoimmune-related pathology, and decreased activated CD8⁺ T cells, showing anti-inflammatory and immunoregulatory effects[1].
Synonyms	Asterin

Chemical Properties

Molecular Weight	570.47
Formula	C₂₅H₃₃Cl₂N₅O₆
Cas No.	148057-23-2
Smiles	O=C1NC(C(=O)N2CC(Cl)C(Cl)C2C(=O)NC(C(=O)NC(C(=O)NC(C=3C=CC=CC3)C1)CO)CC)CC
Relative Density.	1.46g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (140.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7529 mL	8.7647 mL	17.5294 mL	87.6470 mL
5 mM	0.3506 mL	1.7529 mL	3.5059 mL	17.5294 mL
10 mM	0.1753 mL	0.8765 mL	1.7529 mL	8.7647 mL
20 mM	0.0876 mL	0.4382 mL	0.8765 mL	4.3824 mL
50 mM	0.0351 mL	0.1753 mL	0.3506 mL	1.7529 mL
100 mM	0.0175 mL	0.0876 mL	0.1753 mL	0.8765 mL

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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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