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Astin C

Name: Astin C
Brand: TargetMol
SKU: TN3464
Rating: 4.5 (1 reviews)

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Catalog No. TN3464Cas No. 148057-23-2

Alias Asterin

Astin C (Asterin), a naturally occurring cyclic peptide that can be extracted from Aster tataricus, specifically blocks IRF3 recruitment at the STING signalosome inhibiting cGAS-STING signaling and innate inflammatory responses triggered by cytoplasmic dna, resulting in mice that are more susceptible to HSV-1 infection and significantly attenuating autoinflammatory responses.

Astin C

🥰Excellent

Catalog No. TN3464Alias AsterinCas No. 148057-23-2

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Astin C (Asterin), a naturally occurring cyclic peptide that can be extracted from Aster tataricus, specifically blocks IRF3 recruitment at the STING signalosome inhibiting cGAS-STING signaling and innate inflammatory responses triggered by cytoplasmic dna, resulting in mice that are more susceptible to HSV-1 infection and significantly attenuating autoinflammatory responses.
Targets&IC50	Ifnb and Cxcl10 expression (IMR-90 cells via STING pathway):10.8  μM, Ifnb and Cxcl10 expression (MEFs via STING pathway):3.4  μM
In vitro	Astin C (10 μM, 6 h) inhibited the expression of DNA- or HSV-1–induced genes such as Ifnb and Cxcl10 in MEFs and IMR-90 cells, with IC₅₀ values of 3.4 μM and 10.8 μM respectively, indicating it is a STING pathway inhibitorp[1].
In vivo	In Trex1⁻/⁻ mice, Astin C (1 mg/kg, i.v., every other day for 14 days) reduced inflammatory gene expression across multiple tissues, alleviated autoimmune-related pathology, and decreased activated CD8⁺ T cells, showing anti-inflammatory and immunoregulatory effects[1].
Synonyms	Asterin

Chemical Properties

Molecular Weight	570.47
Formula	C₂₅H₃₃Cl₂N₅O₆
Cas No.	148057-23-2
Smiles	O=C1NC(C(=O)N2CC(Cl)C(Cl)C2C(=O)NC(C(=O)NC(C(=O)NC(C=3C=CC=CC3)C1)CO)CC)CC
Relative Density.	1.46g/cm3
Sequence	Cyclo({Abu}-Pro-{Abu}-Ser-{Oaa})
Sequence Short	Cyclo({Abu}-P-{Abu}-S-{Oaa})

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (140.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7529 mL	8.7647 mL	17.5294 mL	87.6470 mL
5 mM	0.3506 mL	1.7529 mL	3.5059 mL	17.5294 mL
10 mM	0.1753 mL	0.8765 mL	1.7529 mL	8.7647 mL
20 mM	0.0876 mL	0.4382 mL	0.8765 mL	4.3824 mL
50 mM	0.0351 mL	0.1753 mL	0.3506 mL	1.7529 mL
100 mM	0.0175 mL	0.0876 mL	0.1753 mL	0.8765 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc