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cGMP Dependent Kinase Inhibitor Peptide acetate
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Synonyms:
Catalog No. TP1903L1 Copy Product Info
Purity: 99.92%
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cGMP Dependent Kinase Inhibitor Peptide acetate is a highly selective, ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG/cGKI). cGMP Dependent Kinase Inhibitor Peptide acetate is a synthetically produced peptide with a Ki value of 86 μM. cGMP Dependent Kinase Inhibitor Peptide acetate inhibits PKG-dependent myosin light chain phosphorylation in vascular smooth muscle cells, blocking vasodilatory signaling, and is used in cardiovascular disease research. cGMP Dependent Kinase Inhibitor Peptide acetate also inhibits PfPKG in Plasmodium and Toxoplasma, and is used in antiparasitic research.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 mg | $31 | - | In Stock | |
| 10 mg | $44 | - | In Stock | |
| 25 mg | $71 | - | In Stock | |
| 50 mg | $103 | - | In Stock | |
| 100 mg | $151 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.92%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | cGMP Dependent Kinase Inhibitor Peptide acetate is a highly selective, ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG/cGKI). cGMP Dependent Kinase Inhibitor Peptide acetate is a synthetically produced peptide with a Ki value of 86 μM. cGMP Dependent Kinase Inhibitor Peptide acetate inhibits PKG-dependent myosin light chain phosphorylation in vascular smooth muscle cells, blocking vasodilatory signaling, and is used in cardiovascular disease research. cGMP Dependent Kinase Inhibitor Peptide acetate also inhibits PfPKG in Plasmodium and Toxoplasma, and is used in antiparasitic research. |
| In vitro | Methods: Brain slices from SD rats (P21–23) containing the medial prefrontal cortex (mPFC) were used to record from layer V pyramidal neurons. A 1 mM solution of cGMP Dependent Kinase Inhibitor Peptide acetate was administered via the recording electrode’s intraslip channel. Whole-cell patch-clamp recordings of EPSCs were performed, and LTD was induced by CCh (50 μM, 10 min). Results: Postsynaptic application of cGMP Dependent Kinase Inhibitor Peptide acetate did not block CCh-induced LTD. [1] |
| Molecular Weight | 1003.16 |
| Formula | C40H78N18O12 |
| Smiles | CC(O)=O.C[C@H](NC(=O)[C@H](CCC\N=C(\N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCC\N=C(\N)N)C(=O)N[C@@H](CCC\N=C(\N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(O)=O |
| Relative Density. | no data available |
| Sequence | H-Arg-Lys-Arg-Ala-Arg-Lys-Glu-OH |
| Sequence Short | RKRARKE |
| Storage | Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Related Tags: cGMP Dependent Kinase Inhibitor Peptide acetate chemical structure | cGMP Dependent Kinase Inhibitor Peptide acetate in vitro | cGMP Dependent Kinase Inhibitor Peptide acetate formula | cGMP Dependent Kinase Inhibitor Peptide acetate molecular weight
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