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BACE2 Protein, Mouse, Recombinant (His)
(Synonyms: β-site APP-cleaving enzyme 2, DRAP, CEAP1, CDA13, beta-site APP-cleaving enzyme 2, BAE2, ASP21, ARP1, ALP56, AI850424, AEPLC, 1110059C24Rik) Copy Product InfoSynonyms: β-site APP-cleaving enzyme 2, DRAP, CEAP1, CDA13, beta-site APP-cleaving enzyme 2, BAE2, ASP21, ARP1, ALP56, AI850424, AEPLC, 1110059C24Rik
Catalog No. TMPY-03065 Copy Product Info
BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged.
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $85 | 7-10 days | 7-10 days | |
| 10 μg | $146 | 7-10 days | 7-10 days | |
| 20 μg | $242 | 7-10 days | 7-10 days | |
| 50 μg | $477 | 7-10 days | 7-10 days | |
| 100 μg | $929 | 7-10 days | 7-10 days | |
| 200 μg | $1,350 | 7-10 days | 7-10 days | |
| 500 μg | $2,720 | 7-10 days | 7-10 days | |
| 1 mg | $5,300 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2 . The specific activity is >50 pmoles/min/μg. |
| Description | BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged. |
| Species | Mouse |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | Q9JL18 |
| Construction | A DNA sequence encoding the mouse BACE2 (Q9JL18) (Met1-Pro462) was expressed with a C-terminal polyhistidine tag. Predicted N terminal: Ala 20 |
| Protein Purity | > 90 % as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | β-site APP-cleaving enzyme 2, DRAP, CEAP1, CDA13, beta-site APP-cleaving enzyme 2, BAE2, ASP21, ARP1, ALP56, AI850424, AEPLC, 1110059C24Rik |
| Research Background | BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged. |
| Molecular Weight | 49.2 kDa (predicted); 55 kDa (reducing condition, due to glycosylation) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: BACE2 Protein, Mouse, Recombinant (His) chemical structure | BACE2 Protein, Mouse, Recombinant (His) molecular weight
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