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SNG-1153

Name: SNG-1153
Brand: TargetMol
SKU: T5348
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5348Cas No. 1446712-19-1

SNG-1153 is a estrogen receptor ER-alpha36 modulator.

SNG-1153

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Purity: 99.74%

Catalog No. T5348Cas No. 1446712-19-1

SNG-1153 is a estrogen receptor ER-alpha36 modulator.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$46	In Stock	In Stock
10 mg	$70	In Stock	In Stock
25 mg	$103	In Stock	In Stock
50 mg	$148	In Stock	In Stock
100 mg	$216	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$55	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.74%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

SNG-1153 AI Summary

SNG-1153 exhibits multiple biological activities. It shows antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 1.16% at a concentration of 10 µM after 48 hours, and by 0.11% in VERO-6 cells under the same conditions, as determined by high content imaging. Additionally, SNG-1153 inhibits the SARS-CoV-2 3CL-Pro protease by 5.187% at 20 µM concentration using a FRET response assay with a peptide substrate. Furthermore, the compound inhibits human HDAC6 activity with 19.1% inhibition using a commercial peptide substrate and 1.77% inhibition with a custom peptide substrate in enzymatic assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

SNG-1153 is a estrogen receptor ER-alpha36 modulator.

Chemical Properties

Molecular Weight	406.35
Formula	C₂₁H₁₇F₃O₅
Cas No.	1446712-19-1
Smiles	CC(C)=CCc1c(O)cc(O)c2c1oc(c(O)c2=O)-c1ccc(cc1)C(F)(F)F
Relative Density.	1.449 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (159.96 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4609 mL	12.3047 mL	24.6093 mL	123.0466 mL
5 mM	0.4922 mL	2.4609 mL	4.9219 mL	24.6093 mL
10 mM	0.2461 mL	1.2305 mL	2.4609 mL	12.3047 mL
20 mM	0.1230 mL	0.6152 mL	1.2305 mL	6.1523 mL
50 mM	0.0492 mL	0.2461 mL	0.4922 mL	2.4609 mL
100 mM	0.0246 mL	0.1230 mL	0.2461 mL	1.2305 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc