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T-0156

Name: T-0156
Brand: TargetMol
SKU: T23411L
Price: 137 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23411LCas No. 324572-92-1

Alias T 0156

T-0156 is a novel, potent and selective phosphodiesterase type 5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinity for PDE6, PDE1, PDE2, PDE3 and PDE4.

T-0156

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Purity: 98.76%

Catalog No. T23411LAlias T 0156Cas No. 324572-92-1

T-0156 is a novel, potent and selective phosphodiesterase type 5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinity for PDE6, PDE1, PDE2, PDE3 and PDE4.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$137	In Stock	In Stock
5 mg	$338	In Stock	In Stock
10 mg	$483	In Stock	In Stock
25 mg	$756	In Stock	In Stock
50 mg	$1,030	In Stock	In Stock
100 mg	$1,370	-	In Stock
200 mg	$1,850	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.76%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	T-0156 is a novel, potent and selective phosphodiesterase type 5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinity for PDE6, PDE1, PDE2, PDE3 and PDE4.
Synonyms	T 0156

Chemical Properties

Molecular Weight	583.59
Formula	C₃₁H₂₉N₅O₇
Cas No.	324572-92-1
Smiles	O=C(OC)C1=C(C=2C=C(OC)C(OC)=C(OC)C2)C=3C=CN=C(OCC4=NC=CC=N4)C3C(=O)N1CC=5C=CN=C(C5)C
Relative Density.	1.329 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (94.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7135 mL	8.5677 mL	17.1353 mL	85.6766 mL
5 mM	0.3427 mL	1.7135 mL	3.4271 mL	17.1353 mL
10 mM	0.1714 mL	0.8568 mL	1.7135 mL	8.5677 mL
20 mM	0.0857 mL	0.4284 mL	0.8568 mL	4.2838 mL
50 mM	0.0343 mL	0.1714 mL	0.3427 mL	1.7135 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc