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Mifobate

Name: Mifobate
Brand: TargetMol
SKU: T16074
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16074Cas No. 76541-72-5

Alias SR-202

Mifobate (SR-202) is a potent and specific antagonist of PPARγ, exhibiting antiobesity, antidiabetic, and antiatherosclerotic effects[1].

Mifobate

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Purity: 99.12%

Catalog No. T16074Alias SR-202Cas No. 76541-72-5

Mifobate (SR-202) is a potent and specific antagonist of PPARγ, exhibiting antiobesity, antidiabetic, and antiatherosclerotic effects[1].

Pack Size	Price	Availability
1 mg	$44	In Stock
5 mg	$113	In Stock
10 mg	$189	In Stock
25 mg	$318	In Stock
50 mg	$473	In Stock
100 mg	$678	In Stock
1 mL x 10 mM (in DMSO)	$126	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.12%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Mifobate (SR-202) is a potent and specific antagonist of PPARγ, exhibiting antiobesity, antidiabetic, and antiatherosclerotic effects[1].
Targets&IC50	PPARγ:140 μM (IC50)
In vitro	SR-202 is a new synthetic PPARgamma antagonist,, which inhibits both TZD-stimulated recruitment of the coactivator steroid receptor coactivator-1 and TZD-induced transcriptional activity of the receptor.?In cell culture, SR-202 efficiently antagonizes hormone- and TZD-induced adipocyte differentiation[1].
In vivo	In vivo, decreasing PPARgamma activity, either by treatment with SR-202 or by invalidation of one allele of the PPARgamma gene, leads to a reduction of both high fat diet-induced adipocyte hypertrophy and insulin resistance.?These effects are accompanied by a smaller size of the adipocytes and a reduction of TNFalpha and leptin secretion.?Treatment with SR-202 also dramatically improves insulin sensitivity in the diabetic ob/ob mice[1].
Synonyms	SR-202

Chemical Properties

Molecular Weight	358.65
Formula	C₁₁H₁₇ClO₇P₂
Cas No.	76541-72-5
Smiles	C(P(OC)(OC)=O)(OP(OC)(OC)=O)C1=CC=C(Cl)C=C1
Relative Density.	1.355g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 35.87 mg/mL (100.01 mM), Sonication and heating are recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.7882 mL	13.9412 mL	27.8823 mL	139.4117 mL
5 mM	0.5576 mL	2.7882 mL	5.5765 mL	27.8823 mL
10 mM	0.2788 mL	1.3941 mL	2.7882 mL	13.9412 mL
20 mM	0.1394 mL	0.6971 mL	1.3941 mL	6.9706 mL
50 mM	0.0558 mL	0.2788 mL	0.5576 mL	2.7882 mL
100 mM	0.0279 mL	0.1394 mL	0.2788 mL	1.3941 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc